The Natriuretic Hormone

de Wardener HE Mills IH Clapham WF Studies on the afferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog. Clin Sci 1961; 21: 249–58.

Bahlmann JS McDonald J Ventom MG The effect on urinary sodium excretion of blood volume expansion without changing the composition of the blood. Clin Sci 1967; 32: 403–13.

de Wardener HE . Natriuretic hormone. Clin Sci Mol Med 1977; 53: 1–8.

Sonnenberg H Veress AT Pearce JW . A humoral component of the natriuretic mechanism in sustained blood volume expansion. J Clin Invest 1972; 51: 2631–44.

Knock CA de Wardener HE . Evidence in vivo for circulating natriuretic substance in rats after expanding the blood volume. Clin Sci 1980; 59: 411–21.

Pearce JW Sonnenberg H Veress AT Evidence for a humoral factor modifying the renal response to blood volume expansion in the rat. Can J Physiol Pharmacol 1969; 47: 377–86.

Lichardus B Pliska V Uhrin V The cow as a model for investigating natriuretic activity. Lancet 1968; i: 127–9.

Nutbourne DM The effect of expanding the blood volume of a dog on the short circuit current across an isolated frog skin incorporated in the dog's circulation. Clin Sci 1970; 38: 629–48.

Clarkson EM Talner LB de Wardener HE . The effect of plasma from blood volume expanded dogs on sodium, potassium and PAH transport of renal tubule fragments. Clin Sci 1970; 38: 617–27.

Gonick HC Kramer HJ Paul W Circulating inhibitor of sodium-potassium-activated adenosine triphosphate after expansion of extracellular fluid volume in rats. Clin Sci Molec Med 1977; 53: 329–34.

Poston L Wilkinson SP Sewell R Inhibition of leucocyte sodium transport during mineralocorticoid ‘escape’. Clin Sci 1980; 58: 90.

Flier JS Maratos-Flier E Pallotta JA Endogenous digitalis-like activity in the plasma of the toad Bufo marinus. Nature 1979; 279: 341–43.

Gruber KA Whitaker JM Buckalew VM Jr Endogenous digitalis-like substance in plasma of volume expanded dogs. Nature 1980; 287: 743–5.

de Wardener HE MacGregor GA Clarkson EM Effect of sodium intake on ability of human plasma to inhibit renal Na⁺-K⁺-Adenosine triphosphatase in vitro. Lancet 1981; i: 411–12.

Fenton S Clarkson EM MacGregor GA . Alaghband-Zadeh J, de Wardener HE. An assay of the capacity of biological fluids to stimulate renal glucose-6-phosphate dehydrogenase (G6PD) activity in vitro as a marker of their ability to inhibit sodium-potassium dependent adenosive triphosphatase (Na⁺-K⁺-ATPase) activity. J. Endocrinol 1982 in press.

Clarkson EM Raw SM de Wardener HE . Further observations on a low molecular weight natriuretic substance in the urine of normal man. Kidney Internal 1979; 16: 710–21.

Lee J de Wardener HE . Neurosecretion and sodium excretion. Kidney Internal 1974; 6: 323–30.

Kaloyanides GJ Cohen L DiBona GF . Failure of selected endocrine organ ablation to modify the natriuresis of blood volume expansion in the dog. Clin Sci Molec Med 1977; 52: 351–6.

Clarkson EM Koutsaimanis KG Davidman M The effect of brain extracts on urinary sodium excretion of the rat and the intracellular sodium concentration of renal tubule fragments. Clin Sci Molec Med 1974; 47: 201–13.

Silva-Netto CR de Mello Aires M Malnic G . Hypothalamic stimulation and electrolyte excretion: A micropuncture study. Am J Physiol 1980; 239: F206–F214.

Haupert GI Saucho JM . Sodium transport inhibitor from bovine hypothalamus. Proc Nat Acad Sci, USA 1979; 76: 4658–60.

Lichstein D Samueloy S . Endogenous ‘ouabain-like’ activity in rat brain. Biochem Biophys Res Comm 1980; 96: 1518–23.

Fishman MC . Endogenous digitalis-like activity in mammalian brain. Proc Nat Acad Sci USA 1979; 76: 4661–3.

Blaustein MP . Sodium ions, calcium ions, blood pressure regulation and hypertension: A reassessment of a hypothesis. Am J Physiol 1977; 232: C165–C173.

de Wardener HE MacGregor GA . Dahl's hypothesis that a saluretic substance may be responsible for a sustained rise in arterial pressure: Its possible role in essential hypertension. Kidney Internal 1980; 18: 1–9.

Poston L Evidence for a circulating sodium transport inhibitor in essential hypertension. Br Med J in press.

MacGregor GA Fenton S Alaghband-Zadeh J Markandu N Roulston JE de Wardener HE . Evidence for a raised concentration of a circulating sodium transport inhibitor in essential hypertension. Br Med J. 1981 283: 1355–7.