The results of investigations on a family after a screening programme for congenital hypothyroidism are presented. The newborn child and her father appeared to have a congenital thyroxine binding globulin deficiency. Problems regarding standard thyroid hormone tests are discussed. It was observed that the free T4 index as well as a commercial free T4 determination introduced earlier can give misleading results. The first experience with another more promising free T4 determination is also presented.
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