An Improved Continuous Flow Method for Serum Creatinine Using the Jaffé Reaction

Abstract

A method for the measurement of creatinine is described in which serum is dialysed directly into a combined alkaline picrate reagent. Baseline noise and drift are eliminated, and precision is improved by avoiding the need to add further reagents after dialysis. This may be of particular interest to laboratories that perform this assay on first-generation AutoAnalyzer equipment.