The commonly used nitration colorimetric method for urgent paracetamol estimation suffers from interference by salicylates and salicylamide. This communication describes a simple modification which eliminates this interference without affecting either the recovery or precision of the method. The results obtained were briefly compared with those obtained by an established gas chromatographic procedure.
References
1.
GlynnJ PKendalS E. Paracetamol Measurement. Lancet1975; 1: 1147.
2.
ChambersR EJonesK. Comparison of a gas chromatographic and colorimetric method for the determination of plasma paracetamol. Ann Clin Biochem1976; 22: 879.
3.
WienerK. Paracetamol Estimation: Comparison of a quick colorimetric method with a standard spectrophotometric method. Ann Clin Biochem1977; 14: 55.
4.
MaceP F KWalkerG. Salicylate interference with plasma paracetamol method. Lancet1976; 2: 1362.
5.
WienerK. A review of methods for plasma paracetamol estimation. Ann Clin Biochem1978; 15: 187.
6.
ChafetzLDalyR ESchriftmanHLomnerJ J. Selective colorimetric determination of acetaminophen. J Pharm Sci1971; 60: 463.
7.
StewartM JWillisR G. Simplified gas chromatographic assay for paracetamol. Ann Clin Biochem1975; 12: 4.
