Plasma 25-hydroxyvitamin D (25-OHD) values in 22 hyperthyroid patients did not differ significantly from those of controls matched for age, sex, and the time of year that plasma samples were taken. In the hyperthyroid group, plasma alkaline phosphatase was significantly higher than in controls, and an increase in bone type alkaline phosphatase occurred in 50 %. In the 18 female hyperthyroid patients the plasma γ-glutamyl transferase was significantly increased compared with controls. Mean values for plasma albumin, alanine transferase, and calcium showed no significant difference between hyperthyroid and control patients.
References
1.
AdamsP. H.JowseyJ.KellyP. J.RiggsB. L.KinneyV. R.JonesJ. D. (1967). Effects of hyperthyroidism on bone and mineral metabolism in man. Quarterly Journal of Medicine, 36, 1–15.
2.
BaxterJ. D.BondyP. K. (1966). Hypercalcaemia of thyrotoxicosis. Annals of Internal Medicine, 65, 429–442.
3.
BouillonR.De MoorP. (1974). Parathyroid function in patients with hyper- or hypothyroidism. Journal of Clinical Endocrinology and Metabolism, 38, 999–1004.
4.
BrownI. R. F.BakowskaA.MillardP. H. (1976). Vitamin D status of patients with femoral neck fractures. Age and Ageing, 5, 127–131.
ChenS.AndersonW.JonesJ. E. (1973). Alkaline phosphatase in hepatobiliary diseases and hyperthyroidism. Pahlavi Medical Journal, 4, 357–365.
7.
ChristensenM. S. (1976). A sensitive radioimmunoassay of parathyroid hormone in human serum using a specific extraction procedure. Scandinavian Journal of Clinical and Laboratory Investigation, 36, 313–322.
8.
CleeveH. J. W. (1978). Origin of an elevated plasma alkaline phosphatase activity in non-jaundiced patients. Annals of Clinical Biochemistry, 15, 86–90.
9.
CookP. B.NassimJ. R.CollinsJ. (1959). The effects of thyrotoxicosis upon the metabolism of calcium, phosphorus and nitrogen. Quarterly Journal of Medicine, 28, 505–529.
10.
CrooksJ.HedleyA. J.MacNeeC.StevensenI. H. (1973). Changes in drug metabolising ability in thyroid disease. British Journal of Pharmacology, 49, 156P–157P.
11.
EichelbaumM.BodemG.GuglerR.Schneider-DetersC.DenglerH. J. (1974). Influence of thyroid status on plasma halt-life of antipyrine in man. New England Journal of Medicine, 290, 1040–1042.
12.
FraserS. A.AndersonJ. B.SmithD. A.WilsonG. M. (1971). Osteoporosis and fractures following thyrotoxicosis. Lancet, 1, 981–983.
13.
FraserS. A.WilsonG. M. (1971). Plasma calcitonin in disorders of thyroid function. Lancet1, 725–726.
14.
HaddadJ. G.Jr.ChyuK. J. (1971). Competitive protein binding radioassay for 25-hydroxycholecalciferol. Journal of Clinical Endocrinology, 33, 992–995.
15.
HahnT. J.HendinB. A.ScharpC.HaddadJ. G.Jr. (1972). Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults. New England Journal of Medicine, 287, 900–904.
16.
HunsteinW.GlessK.-H.Schmidt-GaykH. V.MittelstaedtG.HüfnerM., (1977). Alkaline phosphatase and plasma-25-OH-vitamin D in hyperthyroidism. Hormone and Metabolic Research, 9, 532–533.
17.
IngbarS. H.WoeberK. A. (1974). In Textbook of Endocrinology, 5th edition, edited by WilliamsR. H., p. 160.
18.
KanisJ. A.CundyT.BartlettM.SmithR.HeynenG.WarnerG. T.RussellR. G. G. (1978). Is 24, 25-dihydroxycholecalciferol a calcium-regulating hormone in man?British Medical Journal, 1, 1382–1386.
19.
MosekildeL.LundB.SørensenO. H.ChristensenM. H.MelsenF. (1977). Serum-25-hydroxycholecalciferol in hyperthyroidism. Lancet, 1, 806–807.
20.
PreeceM. A.FordJ. A.McIntoshW. B.DunniganM. G.TomlinsonS.O'RiordanJ. L. H. (1973). Vitamin D deficiency among Asian immigrants to Britain. Lancet, 1, 907–910.
RudeR. K.OldhamS. B.SingerF. R.NicoloffJ. T. (1976). Treatment of thyrotoxic hypercalcaemia with propanolol. New England Journal of Medicine, 294, 431–433.
23.
SinghelakisP.AlevizakiC. C.IkkosD. G. (1974). Intestinal calcium absorption in hyperthyroidism. Metabolism, 23, 311–321.
24.
SkinnerR. K.WillsM. R. (1977). Serum 25-hydroxyvitamin D assay. Evaluation of chromatographic and non-chromatographic procedures. Clinica Chimica Acta, 80, 543–554.
25.
StampT. C. B.PoundJ. M. (1974). Seasonal changes in human plasma levels of 25-hydroxy vitamin D. Nature, 247, 563–565.
26.
TomlinsonS.O'RiordanJ. L. H. (1978). The parathyroids. British Journal of Hospital Medicine, 19, 40–53.
27.
ValentzasC.OreopoulousD. G.FromG.PorretB.RappoportA. (1977). Vitamin D levels in thyrotoxicosis. Lancet, 1, 370–371.
