A relatively simple gas chromatographic procedure is proposed for the analysis of the drug dipropylacetic acid in plasma. The compound is chromatographed, as the free acid after ether extraction. Prior to concentration of the solvent the acid is converted to its potassium salt, then regenerated to the free acid immediately before analysis.
References
1.
BonitatiJ. (1976). Gas-chromatographic analysis for succinimide anticonvulsants in serum: Macro- and micro-scale methods. Clinical Chemistry, 22, 341–345
2.
MeijerJ. W.Hessing-BrandL. (1973). Determination of lower fatty acids, particularly the anti-epileptic dipropylacetic acid, in biological materials by means of micro diffusion and gas chromatography. Clinica chimica acta, 43, 215–222
3.
ToselandP. A.AlbaniM.GauchelF. D. (1975). Organic nitrogen-selective detector used in gas-chromatographic determination of some anticonvulsant and barbiturate drugs in plasma and tissues. Clinical Chemistry, 21, 98–103