Paracetamol Estimation: Comparison of a Quick Colorimetric Method with a Standard Spectrophotometric Method

Abstract

A new colorimetric method for the estimation of plasma paracetamol was slightly modified and compared with a standard spectrophotometric method. Good correlation and no significant difference was found between results by the two procedures. Precision, accuracy, and recovery by the colorimetric method were acceptable. Several drugs were tested for interference in the colorimetric method. Some sulphonamide preparations potentially interfere. On the other hand it is less susceptible than the spectrophotometric method to interference by certain other drugs.

The speed and simplicity of the colorimetric method, together with its satisfactory performance, make it a worthwhile alternative to the spectrophotometric procedure.