The assay of parathyroid hormone has contributed greatly to our understanding of calcium metabolism in health and disease. The most important clinical application of the assay is in the differential diagnosis of hypercalcaemia, which is an increasing clinical problem. PTH assays are of little or no value in the absence of other biochemical data, especially accurate determinations of plasma calcium and phosphate.
References
1.
AddisonG. M.HalesC. N.WoodheadJ. S.O'RiordanJ. L. H.Immunoradiometric assay of parathyroid hormone. J. Endocr.49 (1971) 521.
2.
ArnaudC. D.GoldsmithR. S.BordierP. J.SizemoreG. W.Influence of immunoheterogeneity of circulating parathyroid hormone on results of radioimmunoassays of serum in man. Amer. J. Med.56 (1974) 785.
3.
BensonR. C.RiggsB. L.PickardB. M.ArnaudC. D.Radioimmunoassay of parathyroid hormone in hypercalcaemic patients with malignant disease. Amer. J. Med.56 (1974) 821.
4.
BersonS. A.YalowR. S.AurbachG. D.PottsJ. T.Immunoassay of bovine and human parathyroid hormones. Proc. nat. Acad. Sci. (Wash.)49 (1963) 613.
5.
BuchananG.WestT. E. T.WoodheadJ. S.LowyC.Hypoparathyroidism following pharyngo-laryngo-oesophagectomy. Clin. Oncol.1 (1975) 89.
6.
ClarksonE. M.LuckV. A.HynsonW. V.BaileyR. R.EastwoodJ. B.WoodheadJ. S.ClementsV. R.O'RiordanJ. L. H.De WardenerH. E.The effect of aluminium hydroxide on calcium, phosphorus and aluminium balances, the serum parathyroid hormone concentration and the aluminium content of bone in patients with chronic renal failure. Clin. Sci.43 (1972) 519.
7.
DoppmanJ. L.MelsonG. L.EvensR. G.HammondW. G.Selective superior and inferior thyroid vein catheterization. Invest. Radiol.4 (1969) 97.
8.
KeutmannH. T.The chemistry of parathyroid hormone. Clinics in Endocrinology and Metabolism3 (1974) 173.
9.
MilesL. E. M.HalesC. N.Labelled antibodies and immunological assay systems. Nature (Lond.)219 (1968) 186.
10.
NiallH. D.KeutmannH. T.SauerR.HoganM. L.DawsonB. F.AurbachG. D.PottsJ. T.Theamino acid sequence of bovine parathyroid hormone I. Hoppe-Seylers Z. physiol. Chem.351 (1970) 1586.
11.
O'RiordanJ. L. H.AurbachG. D.PottsJ. T.Immunological reactivity of purified human parathyroid hormone. Proc. nat. Acad. Sci. (Wash.)63 (1969) 692.
12.
O'RiordanJ. L. H.PageJ.KerrD. N. S.WallsJ.MoorheadJ.CrockettR. E.FranzH.RitzE.Hyperparathyroidism in chronic renal failure and dialysis osteodystrophy. Quart. J. Med.39 (1970) 359.
13.
O'RiordanJ. L. H.WoodheadJ. S.RobinsonC. J.ParsonsJ. A.KeutmannH. T.NiallH. D.PottsJ. T.Structure-function studies in parathyroid hormone. Proc. roy. Soc. Med.64 (1971a) 1263.
14.
O'RiordanJ. L. H.KendallB. E.WoodheadJ. S.Pre-operative localisation of parathyroid tumours. Lancet2 (1971b) 1172.
15.
O'RiordanJ. L. H.WatsonL.WoodheadJ. S.Secretion of parathyroid hormone in primary hyperparathyroidism. Clin. Endocr.1 (1972) 149.
PowellD.SingerF. R.MurrayT. M.MinkinC.PottsJ. T.Non-parathyroid hormonal hypercalcaemia in patients with neoplastic diseases. New Engl. J. Med.289 (1973) 176.
18.
PreeceM. A.FordJ. A.McIntoshW. B.DunniganM. G.TomlinsonS.O'RiordanJ. L. H.Vitamin D deficiency among Asian immigrants to Britain. Lancet1 (1973) 907.
19.
ReitzR. E.PollardJ. J.WangC. A.FleischliD. J.CopeO.MurrayT. M.DeftosL. J.PottsJ. T.Localisation of parathyroid adenomas by selective venous catheterization and radioimmunoassay. New Engl. J. Med.281 (1969) 348.
20.
WoodheadJ. S.O'RiordanJ. L. H.The immunological properties of porcine parathyroid hormone. J. Endocr.49 (1971) 79.
21.
WoodheadJ. S.AddisonG. M.HalesC. N.The immunoradiometric assay and related techniques. Brit. med. Bull.30 (1974) 44.
