The level of plasma non-esterified fatty acids (NEFA) was measured by gas-liquid chromatography (GLC) and a titration method in 194 samples collected during pregnancy and from four days to 24 weeks post partum. Both techniques indicated a similar pattern of changes in plasma NEFA associated with pregnancy. The titration estimates of NEFA level were usually greater than those measured by GLC, and there was some suggestion that the disparity between the methods was increased at the end of pregnancy and was reduced at six weeks after delivery.
References
1.
BeckerH.BerleP.WalleA.VoigtK. D.Influence of late gestation and early puerperium on lipid and carbohydrate metabolism in normal females. Acta endocr.62 (1971) 570.
2.
BleicherS. J.O'SullivanJ. B.FreinkelN.The interrelations of glucose, insulin and free fatty acids in late pregnancy and post partum. New Engl. J. Med.271 (1964) 966.
3.
BurtR. L.Plasma nonesterified fatty acids in normal pregnancy and the puerperium. Obstet. Gynec.15 (1960) 460.
4.
DannenbergW. N.BurtR. L.The effect of insulin and glucose on plasma lipids during pregnancy. Amer. J. Obstet. Gynec.92 (1965) 195.
5.
DoleV. P.A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J. clin. Invest.35 (1956) 150.
6.
DoleV. P.MeinertzH.Microdetermination of long-chain fatty acids in plasma and tissues. J. biol. Chem.235 (1960) 2495.
7.
FairweatherD. V. I.Changes in levels of serum, nonesterified fatty acid and blood glucose in pregnancy. J. Obstet. Gynaec. Brit. Cwlth.78 (1971) 707.
8.
McDonald-GibsonR. G.YoungM.The use of an automatic solids injection system for quantitative determination of plasma long chain non-esterified fatty acids by gas-liquid chromatography. Clin. chim. Acta53 (1974) 117.
9.
McDonald-GibsonR. G.YoungM.HyttenF. E.Changes in plasma non-esterified fatty acids and serum glycerol in pregnancy. Brit. J. Obstet. Gynaec.82 (1975) 460.
10.
PicardC.OomsA. A.BalasseE.ConardV.Effect of normal pregnancy on glucose assimilation, insulin and non-esterified fatty acid levels. Diabetologia4 (1968) 16.
11.
PotnisA. V.PurandareB. N.Serum non-esterified (free) fatty acids in pregnancy. J. Obstet. Gynaec. India22 (1972) 120.
12.
QuintoP.BottiglioniF.FlamigniC.Metabolic studies in healthy pregnant women. J. Obstet. Gynaec. Brit. Cwlth.74 (1967) 544.
13.
SvanborgS.VikrotO.Plasma lipid fractions, including individual phospholipids, at various stages of pregnancy. Acta med. scand.178 (1965) 615.
14.
Van DuyneC. M.HavelR. J.The plasma lipids in pregnancy and the newborn. Clin. Obstet. Gynec.3 (1960) 326.