Special Techniques in Clinical Analytical Toxicology I. Gas Chromatography

Much useful information is available in the journals and news sheets published by instrument manufacturers.

‘Analytical News’ Perkin-Elmer Ltd., Beaconsfield.

‘Column’ Pye-Unicam Ltd., Cambridge.

‘Facts and Methods’ Hewlett Packard, Avondale Penn. U.S.A.

‘Previews and Reviews’ Varian Aerograph, Switzerland.

General.

Beckett A. H. Moffatt A. C. Routine detection and identification in urine of stimulants, analgesics, antihistamines, local anaesthetics and other drugs, some of which may be used to modify performance in sport. J. Pharm. Pharmacol. 20 (1968) 485–505.

Cardini C. Quercia V. Calo A. Systematic application of gas chromatography to the analysis of pharmaceutical preparations. J. Chromatog. 37 (1968) 190–193.

McMartin C. Street H. V. Gas liquid chromatography of submicrogram amounts of drugs. 1. Preparation, scope and limitations of columns. J. Chromatog. 22 (1966) 274–285.

Parker K. D. Fontan C. R. Kirk P. L. Rapid gas chromatographic method for screening of toxicological extracts for alkaloids, barbiturates, sympathomimetic and tranquillizers. Anal. Chem. 35 (1963) 356–359.

Walber Techniques in gas chromatography.

Part 1. Gough T. A. Walber E. A. Choice of detectors. Analyst. 95 (1970) 1–15.

Part 2. Palframan J. F. Walber E. A. Choice of solid supports. Analyst. 92 (1967) 71.

Part 3. Walber E. A. Palframan T. F. Developments in the van Deemter rate theory of column performance. Analyst. 94 (1969) 609–615.

Volatiles.

Curry A. S. Walker G. W. Simpson G. S. Determination of ethanol in blood by gas chromatography. Analyst. 91 (1966) 742–743.

Davis R. A. The determination of ethanol in blood or tissue by gas chromatography. Journal of Forensic Sciences 11 (2) (1966) 205–213.

McCord W. M. Gadsden R. H. Identification and determination of alcohols in blood by gas chromatography. J. Gas Chromatog. 2 (1) (1964) 38–39.

Barbiturates.

Brochmann-Hanssen E. Svendsen A. B. Separation and identification of barbiturates and some related compounds by means of gas chromatography. Journal of Pharm. Sciences 51 (4) (1962).

Crippen R. C. Freimuth H. C. Determination of aspirin by gas chromatography. Anal. Chem. 36 (2) (1964) 273–275.

Leach H. Toseland T. A. The determination of barbiturates by gas chromatography. Clin. Chim. Acta. 20 (1968) 195–203.

Maehly A. C. Linturi M. K. Detection of drugs other than barbiturates in the routine method for barbiturate analysis. Acta. Chem. Scand. 16 (1962) 283–286.

Parker K. D. Fontan C. R. Kirk P. L. Improved gas chromatographic column for barbiturates. Anal. Chem. 35 (1963) 418.

Parker K. D. Kirk P. L. Separation and identification of barbiturates by gas chromatography. Anal. Chem. 33 (1961) 1378–1380.

Stevenson G. W. On column methylation of barbituric acids. Anal. Chem. 38 (13) (1966) 1948–1949.

Basic drugs.

Brochmann-Hanssen E. Svendsen A. B. Gas chromatography of alkaloids, alkaloid salts, and derivatives. J. Pharm. Sci. 57 (1962).

Bruce R. B. Maynard W. R. Determination of amphetamine and related amines in blood. Anal. Chem. 41 (1969) 977.

de Silva J. A. F. Schwartz M. A. Stefanovic V. Kaplan J. D'Arconte L. Determination of diazepam (Valium) in blood by gas liquid chromatography. Anal. Chem. 36 (1964) 2099.

de Stefano F. Cartoni G. P. Gas chromatographic determination of amphetamines. Giornale di Biochimica. 12 (5) (1963) 298–311.

Gudzinowics B. J. Analysis of psychoactive phenothiazine drugs by gas chromatography. J. Gas Chromatog. (1966) 110–114.

Lebish P. Finkle B. S. Brackett J. W. Jr. Determination of amphetamines, methamphetamines and related amines in blood and urine by gas chromatography. Clin. Chem. 16 (3) (1970) 195–198.

Mulé S. J. Determination of narcotic analgesics in human biological materials. Anal. Chem. 36 (10) (1964) 1907.

Parker D. Fontan C. R. Kirk P. L. Separation and identification of tranquilizers by gas chromatography. Anal. Chem. 34 (7) (1962) 757–760.

Toseland P. A. Scott P. H. Amphetamine in urine. Clin. Chim. Acta. 25 (1969) 75.

Weder H. J. Bickel M. H. Separation and determination of Imipramine and its metabolites from biological samples by gas liquid chromatography. J. Chromatog. 37 (1968) 181–189.