Does Measurement of Inhibin Have a Clinical Role?

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Burger HG , Robertson DM . Editorial: Inhibin in the male — progress at last. Endocrinol 1997; 138: 1361–2

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Ramaswamy S , Marshall GR , McNeilly AS , Plant TM . Evidence that in a physiological setting Sertoli cell number is the major determinant of circulating concentrations of inhibin B in the adult male rhesus monkey (Macaca mulatta). J Androl 1999; 20: 430–4

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Van Lith JM , Mantingh A , Pratt JJ . First trimester maternal serum immunoreactive inhibin in chromosomally normal and abnormal pregnancies. Obstet Gynecol 1992; 83: 661–4

Van Lith JM , Pratt JJ , Beekhuis JR , Mantingh A. 2nd-trimester serum immunoreactive inhibin as a marker for fetal Down's syndrome. Prenat Diagn 1992; 12: 810–6

Wallace EM , Grant VE , Swanston IA , Groome NP . Evaluation of maternal serum dimeric inhibin A as a first trimester marker of Down's syndrome. Prenat Diagn 1995; 15: 359–62

Wallace EM , Swanston IA , McNeilly AS , Ashby JP , Blundell G , Calder AA , Second trimester screening for Down's syndrome using maternal serum dimeric inhibin A. Clin Endocrinol 1996; 44: 17–21

Cuckle HS , Holding S , Jones R , Wallace EM , Groome NP . Maternal serum dimeric inhibin A in 2nd trimester Down's syndrome pregnancies. Prenat Diagn 1995; 15: 385–6

Aitken DA , Wallace EM , Crossley JA , Swanston IA , van Pareren Y. Dimeric inhibin A as a marker for Down's syndrome in early pregnancy. N Engl J Med 1996; 19: 1231–6

Wald NJ , Densem JW , George L , Muttukrishna S , Knight PG . Prenatal screening for Down's syndrome using inhibin A as a serum marker. Prenatal Diagn 1996; 16: 143–53

Wald NJ , Watt HC , Haddow JE , Knight GJ . Screening for Down's syndrome at 14 weeks of pregnancy. Prenat Diagn 1998; 18: 291–3

Watt HC , Wald NJ , Huttly WJ . The pattern of maternal serum inhibin A concentrations in the second trimester of pregnancy. Prenat Diagn 1998; 18: 846–8

Watt HC , Wald NJ , George L. Maternal serum inhibin A levels in twin pregnancies: Implications for screening for Down's syndrome. Prenat Diagn 1996; 16: 927–9

Wald NJ , Watt HC , George L. Maternal serum inhibin A in pregnancies with insulin-dependent diabetes mellitus. Prenat Diagn 1996; 16: 923–6

Wald NJ , Watt HC . Serum markers for Down's syndrome in relation to number of previous births and maternal age. Prenat Diagn 1996; 16: 699–703

Watt HC , Wald NJ , Smith D , Kennard A , Densem J. Effect of allowing for ethnic group in prenatal screening for Down's syndrome. Prenat Diagn 1996; 16: 691–8

Ferriman EL , Sehmi IK , Jones R , Cuckle HS . The effect of smoking in pregnancy on maternal serum inhibin A levels. Prenat Diagn 1999; 19: 372–4

Wenstrom KD , Owen J , Chu DC , Boots L. Elevated second trimester dimeric inhibin A concentrations identify Down's syndrome pregnancies. Am J Obstet Gynecol 1997; 177: 992–6

Wenstrom KD , Owen J , Chu DC , Boots L. α-fetoprotein, free β human chorionic gonadotrophin, and dimeric inhibin A produce the best results in a three analyte multiple marker screening test for fetal Down's syndrome. Am J Obstet Gynecol 1997; 177: 987–91

Wenstrom KD , Owen J , Chu DC , Boots L. Prospective evaluation of free β-subunit of human chorionic gonadotropin and dimeric inhibin A for aneuploidy detection. Am J Obstet Gynecol 1999; 181: 887–92

Wenstrom KD , Chu DC , Owen J , Boots L. Maternal serum α-fetoprotein and dimeric inhibin A detect aneuploides other than Down's syndrome. Am J Obstet Gynecol 1998; 179: 966–70

Wald NJ , Watt HC , Hackshaw AK . Integrated screening for Down's syndrome based on tests performed during the first and second trimesters. New Engl J Med 1999; 341: 461–7

Editorial. Prenatal screening for Down's syndromes — a search for the family's values. New Engl J Med 1999; 341: 521–2

Muttukrishna S , Knight PG , Groome NP , Redman CWG , Ledger WL . Activin A and inhibin A as possible endocrine markers for pre-eclampsia. Lancet 1997; 349: 1285–8

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Aquilina J , Barnett A , Thompson O , Harrington K. Second trimester maternal serum inhibin A concentration as an early marker for pre-eclampsia. Am J Obstet Gynecol 1999; 181: 131–6

Burger HG , Cahir N , Robertson DM , Groome NP , Dudley E , Green A , Serum inhibin A and B fall differentially as FSH rises in perimenopausal women. Clin Endocrinol 1998; 48: 809–13

Welt CK , McNicholl DJ , Taylor AE , Hall JE . Female reproductive ageing is marked by decreased secretion of dimeric inhibin. J Clin Endocrinol Metab 1999; 84: 105–11

Danforth DR , Arbogast LK , Mroueh J , Kim MH , Kennard EA , Seifer DB , Dimeric inhibin: a direct marker of ovarian ageing. Fertil Steril 1998; 70: 119–23

Seifer DA , Lambert-Messerlian G , Hogan JW , Gardiner AC , Blazar SD , Berk CA . Day 3 inhibin B is predictive of assisted reproductive technologies outcome. Fertil Steril 1997; 67: 110–4

Hofmann GE , Danforth DR , Seifer DB . Inhibin B: the physiologic basis of the clomiphene citrate challenge test for ovarian reserve screening. Fertil Steril 1998; 69: 474–7

Sharara FI , Scott RT , Seifer DB . The detection of diminished ovarian reserve in infertile women. Am J Obstet Gynecol 1998; 179: 804–12

Seifer DB , Scott RT , Bergh PA , Arbogast LK , Friedman CI , Mack CK , Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle-stimulating hormone. Fertil Steril 1999; 72: 63–5

Eldar-Geva T , Robertson DM , Cahir N , Groome NP , Gabbe MP , Maclachlan V , Relationship between serum inhibin A and B and ovarian follicle development following a daily fixed dose administration of recombinant FSH. J Clin Endocrinol Metab 2000; 85: 607–13

Lindheim SR , Chang PL , Vidali A , Ferin M , Sauer MV . The utility of serum progesterone and inhibin A for monitoring natural-cycle IVF-ET. J Assist Reprod Genet 1998; 15: 538–41

Lockwood GM , Ledger WL , Barlow DH , Groome NP , Muttukrishna S. Measurement of inhibin and activin in early human pregnancy: Demonstration of fetoplacental origin and role in prediction of early-pregnancy outcome. Biol Reprod 1997; 57: 1490–4

Lockwood GM , Muttukrishna S , Groome NP , Matthews DR , Ledger WL . Mid-follicular phase pulses of inhibin B are absent in polycystic ovarian syndrome and are initiated by successful laparoscopic ovarian diathermy; a possible mechanism regulating emergence of the dominant follicle. J Clin Endocrinol Metab 1998; 83: 1730–5

von Eckardstein S , Simoni M , Bergmann M , Weinbauer GF , Gassner P , Schepers AG , Serum inhibin B in combination with serum follicle-stimulating hormone (FSH) is a more sensitive marker than serum FSH alone for impaired spermatogenesis in men, but cannot predict the presence of sperm in testicular tissue samples. J Clin Endocrinol Metab 1999; 84: 2496–501

Bohring C , Krause W. Serum levels of inhibin B in men with different causes of spermatogenic failure. Andrologia 1999; 31: 137–41

Foresta C , Bettella A , Petraglia F , Pistorello M , Luisi S , Rossato M. Inhibin B levels in azoospermic subjects with cytologically characterized testicular pathology. Clin Endocrinol 1999; 50: 695–701

Jensen TK , Andersson AM , Hjollund NHI , Scheike T , Kelstad H , Giwercman A , Inhibin B as a serum marker of spermatogenesis: correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men. J Clin Endocrinol Metab 1997; 82: 4059–63

Nachtigall LB , Boepple PA , Seminara SB , Khoury RH , Sluss PM , Lecain AE , Inhibin B secretion in males with gonadotrophin-releasing hormone (GnRH) deficiency before and during long term GnRH replacement: relationship to spontaneous puberty, testicular volume and prior treatment. A clinical research centre study. J Clin Endocrinol Metab 1996; 81: 3520–5

Wallace EM , Groome NP , Riley SC , Parker AC , Wu FCW . Effects of chemotherapy-induced testicular damage on inhibin, gonadotropin and testosterone secretion: a prospective longitudinal study. J Clin Endocrinol Metab 1997; 82: 3111–5

Carlsen E , Olsson C , Petersen JH , Andersson AM , Skakkebaek NE . Diurnal rhythm in serum levels of inhibin B in normal men: relation to testicular steroids and gonadotropins. J Clin Endocrinol Metab 1999; 84: 1664–9

Lappohn RE , Burger HG , Bouma J , Bangah M , Krans M , de Bruijn HWA . Inhibin as a marker for granulosa cell tumors. N Engl J Med 1989; 321: 790–3

Cooke IE , O'Brien M , Charnock FML , Groome NP , Ganesan TS . Inhibin as a marker for ovarian cancer. Br J Cancer 1995; 71: 1046–50

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Lambert-Messerlian GM , Steinhoff M , Zheng W , Canick JA , Gajewski WH , Seifer DB , Multiple immunoreactive proteins in serum from post-menopausal women with epithelial ovarian cancer. Gynecol Oncol 1997; 65: 512–6

Robertson DM , Cahir N , Burger HG , Mamers P , McCloud PI , Pettersson K , Combined inhibin and CA125 assays in the detection of ovarian cancer. Clin Chem 1999; 45: 651–8

Frias AE , Li HZ , Keeney GL , Podratz KC , Woodruff TK . Preoperative serum level of inhibin A is an independent prognostic factor for the survival of postmenopausal women with epithelial ovarian carcinoma. Cancer 1999; 85: 465–71

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Crofton PM , Illingworth PJ , Groome NP , Stirling HF , Swanston IA , Gow S , Changes in dimeric inhibin A and B during normal early puberty in boys and girls. Clin Endocrinol 1997; 46: 109–14

Andersson AM , Toppari J , Havisto AM , Petersen JH , Simell T , Simell O , Longitudinal reproductive hormone profiles in infants: peak of inhibin B levels in infants exceeds levels in adult men. J Clin Endocrinol Metab 1998; 83: 675–81

Andersson AM , Juul A , Petersen JH , Mueller J , Groome NP , Skakkebaek NE . Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty and FSH, LH, testosterone and estradiol levels. J Clin Endocrinol Metab 1997; 82: 3976–81

Byrd W , Bennett MJ , Carr BR , Dong Y , Wians F , Rainey W. Regulation of biologically active dimeric inhibin A and B from infancy to adulthood. J Clin Endocrinol Metab 1998; 83: 2849–54

Seifer DB , Lambert-Messerlian G , Canick JA , Frishman GN , Schneyer AL . Serum inhibin levels are lower in ectopic than intrauterine spontaneously conceived pregnancies. Fertil Steril 1996; 65: 667–9

D'Antona D , Mamers PM , Lowe PJM , Balazs N , Groome NP , Wallace EM . Evaluation of serum inhibin A as a surveillance marker after conservation management of tubal pregnancy. Hum Reprod 1998; 13: 2305–7

Badonnel Y , Barbé F , Legagneur H , Poncelet E , Schweltzer M. Inhibin as a marker for hydatidiform mole: a comparative study with the determinations of intact human chorionic gonadotropin and its free β-subunit. Clin Endocrinol 1994; 41: 155–62

Yamoto M , Imai M , Otani H , Nakano R. Serum levels of inhibin A and inhibin B in women with normal and abnormal luteal function. Obstet Gynecol 1997; 89: 773–6