Leiomyosarcoma of the larynx is an extremely rare malignancy. Until now, only 35 cases have been reported, and only 19 were reported in English. We present 2 new cases observed in the last 3 years at our department. Correct histologic diagnosis can only be made on immunohistochemical and electron microscopic grounds. A 65-year-old man previously treated for a premalignant vocal cord lesion and a 31-year-old woman who previously underwent operation on a benign vocal cord lesion are presented. Only surgical treatment (total laryngectomy and endolaryngeal laser resection) was performed. Thirty-six and 22 months after the initial surgical intervention, both patients are alive and well, with no evidence of local recurrence or distant metastasis.
CottranRSKumarVRobbinsSL. The musculoskeletal system. In: RobbinsSL, ed. Pathologic basis of disease. 4th ed.Philadelphia, Pa: WB Saunders, 1989:1377.
5.
MindellRSCalcaterraTCWardPH. Leiomyosarcoma of the head and neck. Laryngoscope1975;5:904–10.
6.
HaedickeGKabanLB. Smooth-muscle tumors of the oral cavity. Plast Reconstr Surg1988;81:264–9.
7.
ThedingerBACheneyMLMontgomeryWMGoodmanM. Leiomyosarcoma of the trachea. Case report. Ann Otol Rhinol Laryngol1991;100:337–40.
8.
JacksonCJacksonCL. Sarcoma of the larynx. In: JacksonC, ed. Cancer of the larynx. 1st ed.Philadelphia, Pa: WB Saunders, 1939:167–8.
9.
FrankDL. Leiomyosarcoma of the larynx. Arch Otolaryngol1941;34:493–500.
10.
EggstoneAAWolfD. Histopathology of the ear, nose and throat. Baltimore, Md: Williams and Wilkins, 1947:959.
11.
ManaraE. I tumori mesenchimali maligni della laringe. Considerazioni su di un raro caso di leiomiosarcoma. Otorinolaringolltal1959;28:167–78.
12.
PenelliNMazziliG. Leiomiosarcoma della laringe. Arch Ital Laringol1962;70:343–55.
13.
SmolikovaVIErmejevAS. Leiomyosarcoma of the larynx [in Russian]. Vestn Otorinolaryngol1964;24:95–7.
14.
KawabeYKondoT. A laryngeal leiomyosarcoma. Evaluation of the authors' case and observation of the literature. Otolaryngology (Tokyo)1967;39:427–32.
15.
AmendolaL. Leiomiosarcoma della laringe. Valsalva1969;44:268–74.
16.
TalaveraSCoronadoE SeguraHidalgoA Sanchez. Asociación laringocele-leiomiosarcoma de la cuerda vocal. Acta Otorrinolaringol Esp1969;20:74–85.
17.
GryczinskiM. Leiomyosarcoma of the larynx [in Polish]. Otolaryngol Pol1971;25:545–8.
18.
WolfowitzBLSchmamanA. Smooth muscle tumors of the upper respiratory tract. S Afr Med J1973;47:1189–91.
19.
FriedmannI. Sarcomas of the larynx. Can J Otolaryngol1975;4:297–302.
20.
ChizhIOgorodnikovaLSBirinaLMRatnerON. Leiomyosarcoma of the larynx in an 8-year-old girl [in Russian]. Vestn Otorinolaringol1976;36:104–5.
21.
McKillopJHDoigJAKennedyFSThomsonJAGreigWR. Laryngeal malignancy following iodine-125 therapy for thyrotoxicosis. Lancet1978;2:1177–9.
22.
De RosaGPalombiniLD'AngeloL. I leiomiomi della laringe. Rassegna della letteratura e presentazione di 2 casi. Pathologica1978;70:209–15.
23.
KleinsasserOGlanzH. Myogenic tumors of the larynx. Arch Otorhinolaryngol1979;225:107–19.
24.
LehmannWPidouxJMWidmannJJ. Larynx. Microlaryngoscopy and histopathology. Paris, France: Inpharzam Medical Publications, 1981:64–5.
25.
BalestriJGhigiV. Leiomiosarcoma della laringe. Otorinolaringologia1981;31:141–2.
26.
GiordanoCBeatriceFVercellinoN. Un caso dei leiomisarcoma della laringe. Otorinolaringologia1981;31:141.
27.
SokolenkoSMKornilovBEAverinAA. Leiomyosarcoma of the larynx [in Russian]. Vestn Otorinolaringol1984;3:75–8.
28.
LindholmCELofgrenL. Airway repair with pedicled composite grafts. Clinical experience. Otolaryngol Head Neck Surg1987;96:48–54.
29.
Di Luzio PaparattiUPerrazettiFRuggeriL. Un caso dei leiomiosarcoma della laringe. Riv Eur Sci Med Farmacol1988;10:41–4.
30.
ZakARowinskaE. Coexistence of leiomyosarcoma and carcinoma planoepitheliale of the larynx [in Polish]. Wiad Lek1988;41:1387–9.
31.
FukudaHTsujiDHKawasakiYKawaidaMSakouT. Displacement of ventricular fold following cordectomy. Auris Nasus Larynx1990;17:221–8.
32.
BertheauPDeboiseADe RoquancourtABrocheriouC. Léiomyosarcome du larynx. Etude histologique, immunohistochimique et ultrastructurale d'une observation avec revue de la littérature. Ann Pathol1991;11:122–7.
33.
ChenJMNorvickWHLoganCA. Leiomyosarcoma of the larynx. J Otolaryngol1991;20:345–8.
34.
TewaryAKPahorAL. Leiomyosarcoma of the larynx: Emergency laryngectomy. J Laryngol Otol1991;105:134–6.
35.
CarlesDDevarsFSaurelJTraissacLBoudardP. Léiomyosarcome du larynx: Présentation d'un cas. Rev Laryngol Otol Rhinol (Bord)1992;113:115–7.
36.
Rowe-JonesJMSolomonsNBRatcliffeNA. Leiomyosarcoma of the larynx. J Laryngol Otol1994;108:359–62.
37.
Sellari-FranceschiniSSeginiGTestiGBerrettiniSBraschiniPMarcettiG. Leiomyosarcoma of the larynx. Review of the literature and a case report. Rev Laryngol1994;115:345–8.
38.
McKiernanDCWattersGWR. Smooth muscle tumors of the larynx. J Laryngol Otol1995;109:77–9.
39.
HelmbergerRCCrokerBPMancusoAA. Leiomyosarcoma of the larynx presenting as a laryngopyocele. AJNR Am J Neuroradiol1996;17:1112–4.
40.
SamlaliRAcharkiASahraouiSTihyfaMBeniderAKahlainA. Léiomyosarcome du larynx. Revue de la littérature, à propos d'un cas. Bull Cancer (Paris)1996;83:882–5.
41.
LippertBMSchluterEClaassenHWernerJA. Leiomyosarcoma of the larynx. Eur Arch Otorhinolaryngol1997;254:466–9.
42.
OhashiYNakaiYMuraokaMTakanoH. Asymptomatic leiomyosarcoma of maxillary sinus accompanied by primary mucocele. Arch Otorhinolaryngol1984;240:73–8.
43.
KuruvillaAWenigBMHumphreyDMHeffnerDK. Leiomyosarcoma of the sinonasal tract. A clinicopathologic study in nine cases. Arch Otolaryngol1990;116:1278–86.
44.
FranquemontDWGearyW. Gastrointestinal stromal tumors and proliferating cell nuclear antigen [Editorial]. Am J Pathol1993;100:369.
45.
FerenczyARichardtRMOkagakiT. A comparative ultrastructural study of leiomyosarcoma, cellular leiomyoma and leiomyoma of the uterus. Cancer1971;28:1004–18.
46.
TranLMMarkRMeierRCalcaterraTCParkerRG. Sarcomas of the head and neck. Prognostic factors and treatment strategies. Cancer1992;70:169–77.
