Basaloid squamous cell carcinoma is a recently recognized variant of squamous cell carcinoma. The lesion is histologically distinctive and manifests a predilection for the supraglottis, pyriform sinus, and tongue base. The immunohistochemical profile is discussed. The differential diagnoses include adenoid cystic carcinoma, small cell neuroendocrine carcinoma, basal cell adenocarcinoma, adenosquamous carcinoma, squamous cell carcinoma, spindle cell squamous carcinoma, mucoepidermoid carcinoma, and adenoid squamous cell carcinoma. Basaloid squamous cell carcinoma is a biologically high-grade tumor with a propensity for nodal as well as systemic metastases. It is a morphologic and phenotypic entity with a separate prognostic significance.
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References
1.
WainSLKierRVollmerRTBossenEH. Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx. Report of 10 cases. Hum Pathol1986; 17: 1158–66.
2.
World Health Organization. Histological typing of rumours of the upper respiratory tract and ear. Berlin, Germany: Springer-Verlag, 1991.
3.
MoroDBrichonP-YBrambillaEVealeDLabatFBrambillaC. Basaloid bronchial carcinoma. A histologic group with a poor prognosis. Cancer1994; 73: 2734–9.
4.
TsangWYWChanJKCLeeKCLeungAKFFuYT. Basaloid-squamous carcinoma of the upper aerodigestive tract and so-called adenoid cystic carcinoma of the oesophagus: The same tumour type?Histopathology1991; 19: 35–46.
5.
DoughertyBGEvansHL. Carcinoma of the anal canal. A study of 79 cases. Am J Clin Pathol1985; 83: 159–64.
6.
FerryJAScullyRE. “Adenoid cystic” carcinoma and adenoid basal carcinoma of the uterine cervix. A study of 28 cases. Am J Surg Pathol1988; 12: 134–44.
7.
BrambillaEMoroDVealeD. Basal cell (basaloid) carcinoma of the lung: A new morphologic and phenotypic entity with separate prognostic significance. Hum Pathol1992; 23: 993–1003.
8.
NorrisHJMcCauleyKM. Adenoid basal cell carcinoma. Unusual forms of adenocarcinoma of the cervix: An update. In: RosenPPFechnerRE, eds. Pathology annual. Norwalk: Appleton & Lange, 1993(part l): 88–9.
9.
McKayMJBilousAM. Basaloid-squamous carcinoma of the hypopharynx. Cancer1989; 63: 2528–31.
10.
LunaMAEl-NaggarAParichatikanondPWeberRSBatsakisJG. Basaloid squamous carcinoma of the upper aerodigestive tract. Clinicopathologic and DNA flow cytometric analysis. Cancer1990; 66: 537–42.
11.
ShviliYTalmiYPGalRKesslerEKolkovZZoharY. Basaloid-squamous carcinoma of the larynx metastatic to the skin of the nasal tip. J Craniomaxillofac Surg1990; 18: 322–4.
12.
SeidmanJDBermanJJYostBAIseriOA. Basaloid squamous carcinoma of the hypopharynx and larynx associated with second primary tumors. Cancer1991; 68: 1545–9.
13.
BanksERFriersonHFJrMillsSEGeorgeEZarboRJSwansonPE. Basaloid squamous cell carcinoma of the head and neck. A clinicopathologic and immunohistochemical study of 40 cases. Am J Surg Pathol1992; 16: 939–46.
14.
CadierMAKellySAParkhouseNBroughMD. Basaloid squamous carcinoma of the buccal cavity. Head Neck1992; 14: 387–91.
15.
GartlanMGGoetzSPGrahamSM. Basaloid-squamous carcinoma (BSC) of the larynx. Pathologic quiz case 1. Arch Otolaryngol Head Neck Surg1992; 118: 1000–1.
16.
GuarinoMMicoliG. Basaloid-squamous carcinoma of the upper aerodigestive tract [Letter]. Histopathology1992; 20: 462.
17.
LovejoyHMMatthewsBL. Basaloid-squamous carcinoma of the palate. Otolaryngol Head Neck Surg1992; 106: 159–62.
18.
O'MalleyBWJr. Basaloid-squamous carcinoma of the right piriform sinus. Pathologic quiz case 2. Arch Otolaryngol Head Neck Surg1992; 118: 212–3, 215.
19.
PuxedduRBarezzaniMGNicolaiPAntonelliARAgostiniCFacchettiF. Basaloid squamous carcinoma of the laryngo-pharyngeal region. In: The new frontiers of otorhinolaryngology in Europe. 2nd Eur Cong Otorhinolaryngol Cerv-Fac Surg, Monduzzi, Bologna, Italy, 1992; II: 415–8.
20.
TsangWYWChanJKC. Basaloid-squamous carcinoma of the upper aerodigestive tract [Letter]. Histopathology1992; 20: 462.
21.
WanSKChanJKCTseKC. Basaloid-squamous carcinoma of the nasal cavity. J Laryngol Otol1992; 106: 370–1.
22.
CoppolaDCatalanoETangC-KElfenbeinIBHarwickRMohrR. Basaloid squamous cell carcinoma of floor of mouth. Cancer1993; 72: 2299–305.
23.
KlijanienkoJEl-NaggarAPonzio-PrionAMarandasPMicheauCCaillaudJ-M. Basaloid squamous carcinoma of the head and neck. Immunohistochemical comparison with adenoid cystic carcinoma and squamous cell carcinoma. Arch Otolaryngol Head Neck Surg1993; 119: 887–90.
24.
Kwok-FaimaT. Fine needle aspiration cytodiagnosis of basaloid-squamous cell carcinoma metastatic to a cervical lymph node [Letter]. Acta Cytol1993; 37: 977–9.
25.
LarnerJMMalcolmRHMillsSEFriersonHFBanksERLevinePA. Radiotherapy for basaloid squamous cell carcinoma of the head and neck. Head Neck1993; 15: 249–52.
26.
EreñoCLopezJISanchezJMToledoJD. Basaloid-squamous cell carcinoma of the larynx and hypopharynx. A clinicopathologic study of 7 cases. Pathol Res Pract1994; 190: 186–93.
27.
RaslanWFBarnesLKrauseJRContisLKilleenRKapadiaSB. Basaloid squamous cell carcinoma of the head and neck: A clinicopathologic and flow cytometric study of 10 new cases with review of the English literature. Am J Otolaryngol1994; 15: 204–11.
28.
HellquistHBDahlFKarlssonMGNilssonC. Basaloid squamous cell carcinoma of the palate. Histopathology1994; 25: 178–80.
29.
MullerSBarnesL. Basaloid squamous cell carcinoma of the head and neck with a spindle cell component. An unusual histologic variant. Arch Pathol Lab Med1995; 119: 181–2.
30.
WenigB. Atlas of head and neck pathology. Philadelphia, Pa: WB Saunders, 1993: 227–66.
31.
BanksERFriersonHFJrCovellJL. Fine needle aspiration cytologic findings in metastatic basaloid squamous cell carcinoma of the head and neck. Acta Cytol1992; 36: 126–31.
32.
FerlitoA. Unusual forms of squamous carcinoma. In: FerlitoA, ed. Surgical pathology of laryngeal neoplasms. London, England: Chapman and Hall, 1996: 143–71.
33.
ConleyJDingmanDL. Adenoid cystic carcinoma in the head and neck (cylindroma). Arch Otolaryngol1974; 100: 81–90.
34.
SpiroRHHuvosAGStrongEW. Adenoid cystic carcinoma of salivary origin. A clinicopathologic study of 242 cases. Am J Surg1974; 128: 512–20.
35.
FerlitoA. Diagnosis and treatment of small cell carcinoma of the larynx: A critical review. Ann Otol Rhinol Laryngol1986; 95: 590–600.
36.
GneppDR. Small cell neuroendocrine carcinoma of the larynx. Critical review of the literature. ORL J Otorhinolaryngol Relat Spec1991; 53: 210–9.
37.
LunaMABatsakisJGTortoledoEdel JuncoGW. Carcinomas ex monomorphic adenoma of salivary glands. J Laryngol Otol1989; 103: 756–9.
38.
EllisGLWiscovitchJG. Basal cell adenocarcinomas of the major salivary glands. Oral Surg Oral Med Oral Pathol1990; 69: 461–9.
39.
GerughtyRMHenningarGRBrownFM. Adenosquamous carcinoma of the nasal, oral, and laryngeal cavities. A clinicopathologic survey of ten cases. Cancer1968; 22: 1140–54.
40.
Martinez-MadrigalFBadenECasiraghiOMicheauC. Oral and pharyngeal adenosquamous carcinoma. A report of four cases with immunohistochemical studies. Eur Arch Otorhinolaryngol1991; 248: 255–8.
