A retrospective review of 193 previously untreated patients with primary supraglottic carcinoma was undertaken to ascertain the efficacy of postoperative radiotherapy. All the patients received a supraglottic laryngectomy, and patients received a total of 284 elective or therapeutic neck dissections. Ninety-four (48.7%) of the patients received postoperative radiotherapy. The incidence of local recurrence was 8.2%, but the recurrence rate was unrelated to the use of postoperative radiotherapy. Neck recurrence was observed in 12.9% of patients, with no influence of postoperative radiotherapy in the dissected neck. The incidence of locoregional recurrences by stage in irradiated and nonirradiated patients did not reach significant difference. The 3-year survival was 74.3%. The overall survival of the whole series and by stage was not statistically altered in combined therapy compared to surgery.
DevideniVRSimpsonJRSessionsD. Supraglottic carcinoma: impact of radiation therapy on outcome of patients with positive margins and extracapsular nodal disease. Laryngoscope1991; 101: 767–70.
2.
SpauldingCAConstableWCLevinePACantrellRW. Partial laryngectomy and radiotherapy for supraglottic cancer: a conservative approach. Ann Otol Rhinol Laryngol1989; 98: 125–9.
3.
RobbinsKTDavidsonWPetersLJGoepfertH. Conservation surgery for T2 and T3 carcinomas of the supraglottic larynx. Arch Otolaryngol Head Neck Surg1988; 114: 421–6.
4.
BursteinFDCalcaterraTC. Supraglottic laryngectomy: series report and analysis of results. Laryngoscope1985; 95: 833–6.
5.
SooKCShahJPGopinathKSGeroldFPJaquesDPStrongEW. Analysis of prognostic variables and results after supraglottic laryngectomy. Am J Surg1988; 156: 301–5.
6.
BoccaEPignataroOOldiniC. Supraglottic laryngectomy: 30 years of experience. Ann Otol Rhinol Laryngol1983; 92: 14–8.
7.
DeSantoLW. Cancer of the supraglottic larynx: a review of 260 patients. Otolaryngol Head Neck Surg1985; 93: 705–11.
8.
LutzCKJohnsonJTWagnerRLMyersEN. Supraglottic carcinoma: patterns of recurrence. Ann Otol Rhinol Laryngol1990; 99: 12–7.
9.
HermanekPSobinLH. UICC-TNM classification of malignant tumors. Geneva, Switzerland: UICC, 1980.
10.
AlonsoJM. Conservative surgery of cancer of the larynx. Trans Am Acad Ophthalmol Otolaryngol1947; 51: 633–42.
11.
SuárezO. El problema de las metástasis linfáticas y alejadas del cáncer de laringe e hipofaringe. Rev Otorrinolaringol1963; 23: 83–99.
12.
GavilánCBlancoASuárezC. El vaciamiento funcional radical cervicoganglionar: anatomía quirúrgica, técnica y resultados. Acta Otorinolaringol Iberoam1972; 23: 703–817.
13.
OguraJHMarksJEFreemanRB. Results of conservation surgery for cancers of the supraglottis and pyriform sinus. Laryngoscope1980; 90: 591–600.
LeeNKGoepfertHWendtCD. Supraglottic laryngectomy for intermediate-stage cancer: U.T. M.D. Anderson Cancer Center experience with combined therapy. Laryngoscope1990; 100: 831–6.
16.
BoccaEPignataroOOldiniCSambataroGCappaC. Extended supraglottic laryngectomy. Review of 84 cases. Ann Otol Rhinol Laryngol1987; 96: 384–6.
17.
HarwoodAR. Cancer of the larynx: the Toronto experience. J Otolaryngol1982; 11(supp1 11): 10–3.
18.
MendenhallWMParsonsJTStringerSPCassisiNJMillionRR. Carcinoma of the supraglottic larynx: a basis for comparing the results of radiotherapy and surgery. Head Neck Surg1990; 12: 204–9.
19.
FletcherGHJesseRHLindbergRDKoonsCR. The place of radiotherapy in the management of squamous cell carcinoma of the supraglottic larynx. Am J Roentgenol1970; 108: 19–26.
20.
StrijbosMVan den BroekPManniJJHuygenPLM. Supraglottic laryngectomy: short- and long-term functional results. Clin Otolaryngol1987; 12: 265–70.
21.
LevendagPSessionsRVikramB. The problem of neck relapse in early stage supraglottic larynx cancer. Cancer1989; 63: 345–8.
22.
SchullerDEMcGuirtWFKrauseCJMcCabeBFPflugBK. Increased survival with surgery alone vs. combined therapy. Laryngoscope1979; 89: 582–94.
23.
SuárezCLlorenteJLNúñezFDíazCGómezJ. Neck dissection with or without radiotherapy in supraglottic carcinomas. Otolaryngol Head Neck Surg1993: 109: 3–9.
24.
GavilánCGavilánJ. Five-year results of functional neck dissection for cancer of the larynx. Arch Otolaryngol Head Neck Surg1989; 115: 1193–6.
25.
BoccaECalearoCDe VicentiisIMarulloTMottaGOttavianiA. Occult metastases in cancer of the larynx and their relationship to clinical and histological aspects of the primary tumor: a four-year multicentric research. Laryngoscope1984; 94: 1086–90.
26.
SuárezCHerreraFDíazCGómezJBartheP. Prognostic factors in supraglottic carcinoma. In: SacristánTAlvarez-VicentJJBartualJAntoli-CandelaFRubioL, eds. Otorhinolaryngology—head and neck surgery. Amsterdam, the Netherlands: Kugler & Ghedini, 1990: 2481–3.
27.
MarksJEFreemanRBLeeFOguraJH. Carcinoma of the supraglottic larynx. Am J Roentgenol1979; 132: 255–60.
28.
LevendagPVikramB. The problem of neck relapse in early stage supraglottic cancer. Results of different treatment modalities for the clinically negative neck. Int J Radiat Oncol Biol Phys1987; 13: 1621–4.
29.
WeberPCJohnsonJTMyersEN. Impact of bilateral neck dissection on recovery following supraglottic laryngectomy. Arch Otolaryngol Head Neck Surg1993; 119: 61–4.
30.
AmdurRJParsonsJTMendenhallWMMillionRRStringerSPCassisiNJ. Postoperative irradiation for squamous cell carcinoma of the head and neck: an analysis of treatment results and complications. Int J Radiat Oncol Biol Phys1989; 16: 25–36.
31.
MantravadiRVPHaasRELiebnerEJ. Postoperative radiotherapy for persistent tumor at the surgical margin in head and neck cancers. Laryngoscope1983; 93: 1337–40.
32.
JacobsJRAhmadKCasianoR. Implications of positive surgical margins. Laryngoscope1993; 103: 64–8.
