Episodes of acute otitis media frequently occur in childhood and are attended by significant morbidity, such as hearing loss and possible speech delay. Bacteria play an important etiologic role in the pathogenesis of otitis media; therefore, antimicrobial agents are the cornerstone in the treatment of this disease. Many antimicrobial choices are available for treating children with acute otitis media. To choose an antimicrobial for each patient, consideration must be given to the patient's age, history of otitis media episodes, and responses to previously used antimicrobial drugs, and the regional antimicrobial susceptibility of the otitis media pathogens.
CanafaxDMGiebinkGS. Clinical and pharmacokinetic basis for the antimicrobial treatment of acute otitis media. Otolaryngol Clin North Am1991; 24: 859–76.
2.
GiebinkGSCanafaxDM. Controversies in the management of acute otitis media. Adv Pediatr Infect Dis1988; 3: 47–63.
3.
GiebinkGS. Progress in understanding the pathophysiology of otitis media. Pediatr Rev1989; 11: 133–8.
4.
ParadiseJL. On classifying otitis media as suppurative or nonsuppurative with a suggested clinical schema. J Pediatr1987; 11: 948–52.
5.
RosenfeldRMVertreesJCarrJ. Clinical efficacy of antimicrobials for acute otitis media: meta-analysis of 4,700 children from 33 randomized trials. J Pediatr (in press).
6.
GiebinkGS. Introduction: Symposium on the pathophysiology of otitis media. Ann Otol Rhinol Laryngol1990; 99(Suppl 148): 4–5.
