The upper aerodigestive tracts, particularly the larynx, are not uncommon repositories for amyloid. In most instances amyloidosis of the larynx is localized and is not associated with or followed by systemic disease. Oral and nasopharyngeal amyloidoses, on the other hand, are very often manifestations of systemic predisposing disorders. Laryngeal amyloidosis is treated, when indicated, by surgical removal, often repeated because of persistence or multifocal deposits.
Get full access to this article
View all access options for this article.
References
1.
LewisJEOlsenKDKurtinPJKyleRA. Laryngeal amyloidosis: a clinicopathologic and immunohistochemical review. Otolaryngol Head Neck Surg1992; 106: 372–7.
2.
GlennerGC. Amyloid deposits and amyloidosis. The β-fibrilloses. N Engl J Med1980; 302: 1333–43.
3.
KisilevskyR. Amyloidosis: a familiar problem in the light of current pathogenetic developments. Lab Invest1983; 49: 381–90.
4.
KyleRAGreippPR. Amyloidosis (AL). Clinical laboratory features in 229 cases. Mayo Clin Proc1983; 58: 665–83.
5.
KisilevskyR. Amyloid and amyloidosis: differences, common themes and practical considerations. Mod Pathol1991; 4: 514–7.
6.
CohenASConnorsLH. The pathogenesis and biochemistry of amyloidosis. J Pathol1987; 151: 1–7.
7.
ChastonayPHurlimannJ. Characterization of different amyloids with immunological techniques. Pathol Res Pract1986; 181: 657–63.
8.
MufarijAABusabaNYZaytounGMGaloGRFeinerHD. Primary localized amyloidosis of the nose and paranasal sinuses. A case report with immunohistochemical observations and a review of the literature. Am J Surg Pathol1990; 14: 379–83.
9.
YamaguchiANasuMEsakiYShimadaHYoshikiS. Amyloid deposits in the aged tongue. A postmortem study of 107 individuals over 60 years of age. J Oral Pathol1982; 11: 237–44.
10.
Van der WalNHenzen-LogmansSvan der KwastWAMvan der WaalI. Amyloidosis of the tongue: a clinical and postmortem study. J Oral Pathol1984; 13: 632–9.
11.
SimpsonGTSkinnerMStrongMSCohenAS. Localized amyloidosis of the head and neck and upper aerodigestive and lower respiratory tracts. Ann Otol Rhinol Laryngol1984; 93: 374–9.
12.
MichaelsLHyamsVJ. Amyloid in localized deposits and plasmacytomas of the respiratory tract. J Pathol1979; 128: 29–38.
13.
HuiANKossMNHochholzerLWehuntWD. Amyloidosis presenting in the lower respiratory tract. Clinicopathologic, radiologic, immunohistochemical, and histochemical studies on 48 cases. Arch Pathol Lab Med1986; 110: 212–8.