Acinic cell carcinomas display varied cytoarchitectural patterns of growth that should allow for formulation of histopathologic grading. Grading of these carcinomas may serve to identify subsets whose biologic behavior is more aggressive than the usually accepted low-grade behavior of acinic cell carcinomas as a group. To that end, a three-level histopathologic grading scheme is presented.
Get full access to this article
View all access options for this article.
References
1.
EllisGLCorioRL. Acinic cell adenocarcinoma. A clinicopathologic analysis of 294 cases. Cancer1983; 52: 542–9.
2.
AbramsAMCornynJScofieldHHHansenLS. Acinic cell adenocarcinoma of the major salivary glands. A clinicopathologic study of 77 cases. Cancer1965; 18: 1145–62.
3.
PerzinKHLiVolsiVA. Acinic cell carcinomas arising in salivary glands. A clinicopathologic study. Cancer1979; 44: 1434–57.
4.
SpiroRHHuvosAGStrongEW. Acinic cell carcinoma of salivary origin. A clinicopathologic study of 67 cases. Cancer1978; 41: 824–935.
5.
BatsakisJGRegeziJARepolaDA. The pathology of head and neck tumors: Salivary glands, part 2. Head Neck Surg1978; 1: 167–80.
6.
BatsakisJGChinnEKWeimertTAWorkWPKrauseCJ. Acinic cell carcinoma: A clinicopathologic study of thirty-five cases. J Laryngol Otol1979; 93: 325–40.
7.
ThackrayACLucasRB. Tumors of the major salivary glands. Atlas of tumor pathology. Fascicle 10. Washington, DC: Armed Forces Institute of Pathology, 1974: 81–90.
RegeziJABatsakisJG. Histogenesis of salivary gland neoplasms. Otolaryngol Clin North Am1977; 10: 297–307.
10.
BatsakisJG. Salivary gland neoplasia: An outcome of modified morphogenesis and cytodifferentiation. Oral Surg Oral Med Oral Pathol1980; 49: 229–32.
11.
ChaudhryAPCutlerLSLeiferCSatchidanandSLabayGYamaneG. Histogenesis of acinic cell carcinoma of the major and minor salivary glands. An ultrastructural study. J Pathol1986; 148: 307–20.
12.
GustafssonHCarlsööBHenrikssonR. Ultrastructural morphometry and secretory behavior of acinic cell carcinoma. Cancer1985; 55: 1706–10.
13.
StanleyRJWeilandLHOlsenKDPearsonBW. Dedifferentiated acinic cell (acinous) carcinoma of the parotid gland. Otolaryngol Head Neck Surg1988; 98: 155–61.
14.
BatsakisJGLunaMA. Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas. Ann Otol Rhinol Laryngol1990; 99: 835–8.
15.
ErlandsonRATandlerB. Ultrastructure of acinic cell carcinoma of the parotid gland. Arch Pathol1972; 93: 130–40.
16.
BloomGDHenrikssonR. Some ultrastructural features of acinic cell carcinoma. J Laryngol Otol1977; 91: 947–58.
17.
BatsakisJG. Histopathologic grading of salivary gland neoplasms: III. Adenoid cystic carcinomas. Ann Otol Rhinol Laryngol1990 (in press).
18.
GustafssonHLindholmCCarlsööB. DNA cytophotometry of acinic cell carcinoma and its relation to prognosis. Acta Otolaryngol (Stockh)1987; 104: 370–6.
19.
HamperKMauschH-ECaselitzJ. Acinic cell carcinoma of the salivary glands: The prognostic relevance of DNA cytophotometry in a retrospective study of long duration (1965–1987). Oral Surg Oral Med Oral Pathol1990; 69: 68–75.
20.
SpiroRH. Salivary neoplasms: Overview of a 35-year experience with 2807 patients. Head Neck Surg1986; 8: 177–84.
21.
SpiroRHArmstrongJHarrisonLGellerNCLinS-YStrongEW. Carcinoma of major salivary glands. Recent trends. Arch Otolaryngol Head Neck Surg1989; 115: 316–21.
