True malignant mixed tumor, or carcinosarcoma, of salivary gland origin is rare. Only 19 cases have been reported in the literature, and a review of cases seen at the University of Iowa over the last 60 years yielded only two. In one case the mesenchymal component of the tumor contained both osteosarcoma and chondrosarcoma. In the second case, the history and the histology suggest a progression from a carcinoma ex pleomorphic adenoma to a carcinosarcoma. These features are documented in this report and literature review.
ChenKTK. Metastasizing pleomorphic adenoma of the salivary gland. Cancer1978; 42: 2407–11.
3.
TortoledoMELunaMABatsakisJG. Carcinoma ex pleomorphic adenoma and malignant mixed tumors: Histomorphologic indexes. Arch Otolaryngol1984; 110: 172–6.
4.
StephenJBatsakisJGLunaMAvon der HeysenUByersRM. True malignant mixed tumors (carcinosarcoma) of salivary glands. Oral Surg Oral Med Oral Pathol1986; 61: 597–602.
5.
ChenKTKWeinbergRAMoseleyD. Carcinosarcoma of the salivary gland. Am J Otolaryngol1984; 5: 415–7.
6.
Surveillance epidemiology, end results, incidence and mortality data, 1973–1977. National Cancer Institute monograph 576, National Institutes of Health publication 81-2330. Bethesda, Md: US Department of Health and Human Services, 1981: 138.
7.
KirklinJWMcDonaldJRHarringtonSW. Parotid tumors: Histopathology, clinical behavior and end results. Surg Gynecol Obstet1951; 92: 721–33.
