Influence of Growth Hormone on Nasal Septal Growth in Rats

Abstract

Growth activity of the rat septal cartilage was evaluated by incorporating radiolabeled sulfate into three areas of the septal cartilage (anterior, central, and posterior). Growth activity of the septal cartilage was determined in normal rats and in hypophysectomized rats treated either with saline or human growth hormone (hGh) injections. Human growth hormone treatment selectively stimulated sulfate incorporation in the posterior area, which is situated anterior to the septoethmoidal junction, whereas sulfate incorporation was not influenced in the anterior and central area by hGh treatment compared to saline treatment. However, both wet and dry weight was significantly increased by hGh treatment compared to saline treatment in hypophysectomized rats.

Keywords

human growth hormone treatment hypophysectomized rats rat nasal septal cartilage sulfate incorporation

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References

Baume

. The postnatal growth activity of the nasal cartilage septum. Helv Odontol Acta 1961; 5: 9–13.

Petrovic

Charlier

Herman

. Les mécanismes de croissance du croissance du crâne. Recherche sur le cartilage de la cloison nasale et sur les sutures crâniennes et faciales du jeune rat en culture d'organe. Bull Assoc Anat (Nancy) 1968; 143: 1376–81.

Kvinnsland

. Partial resection of the cartilaginous nasal septum in rats: Its influence on growth. Angle Orthod 1974; 44: 135–40.

Petrovic

Stutzmann

. Hormone somatotrope: Modalités d'action sur la croissance des diverses variétés de cartilage. Pathol Biol (Paris) 1980; 28: 43–58.

Searls

. A comparative study of chondrocytic proliferation in nasal septal cartilage of the 5 day old rat, rabbit, guinea pig and beagle. Am J Anat 1979; 154: 437–46.

Vilmann

Moss

. Studies on orthocephalization. Acta Anat (Basel) 1980; 107: 330–5.

Catala

Johnston

Jr . Interstitial growth of septal cartilage in the young albino rat. J Dent Res 1980; 59: 1453–6.

Sarnat

Selman

. Growth pattern of the rabbit nasal bone region. Rhinology 1982; 20: 93–106.

Diewert

. Differential changes in cartilage cell proliferation and cell density in the rat craniofacial complex during secondary palate development. Anat Rec 1980; 198: 219–28.

10.

Hall

. Human somatomedin. Acta Endocrinol (Copenh) 1972; 71: 12–24.

11.

Schoenle

Zapf

Humbel

Froesch

. Insulin like growth factor I stimulates growth in hypophysectomized rats. Nature 1982; 296: 252–3.

12.

Guenther

Froesch

Fleisch

. Effect of insulin like growth factor on collagen and glycosaminoglycan synthesis by rabbit articular chondrocytes in culture. Experientia 1982; 38: 979–81.

13.

Baetzner

Fehm

Voigt

Schleyer

Pfeiffer

. Measurement of biological activity in various growth hormone preparations using a modified tibia test. Acta Endocrinol (Copenh) 1972; 70: 231–8.

14.

Van den Brande

Du Caju

MVL

. An improved technique for measuring somatomedin activity in vitro. Acta Endocrinol (Copenh) 1974; 75: 233–42.

15.

Mastenbroek

. The influence of partial resection of the nasal septum on the growth of the upper jaw and nose [Thesis]. Amsterdam: University of Amsterdam, 1978.

16.

Kvinnsland

Breistein

. Regeneration of the cartilaginous nasal septum in the rat after resection. Plast Reconstr Surg 1973; 51: 190–5.

17.

Stutzmann

Petrovic

. Experimental analysis of general and local extrinsic mechanisms controlling upper jaw growth. Ann Arbor: University of Michigan, 1976: 205–38 ( McNamara

, ed. Craniofacial growth series; Monograph 6).

18.

Kvinnsland

. Transplantation studies of the nasal septal cartilage in rats. Ann Arbor: University of Michigan, 1976: 239–49 ( McNamara

, ed. Craniofacial growth series; Monograph 6).

19.

Vetter

Gammert

Pirsig

Landolt

Heinze

. Growth activities of the nasal septal cartilage in acromegaly. Rhinology 1984; 22: 125–31.