Recent advances in immunology have resulted in an entirely new approach to the classification of the non-Hodgkin's lymphomas based on immune function. Previous classifications, still in use today, are based on morphology and although prognostically useful, are imprecise and include diverse disease entities. The present report reviews the evolution of these classifications and emphasizes the prognostic, therapeutic, and conceptual advantages of the functional (immunologic) approach to the study of lymphomas.
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