A new hypothesis of etiopathogenesis of Meniere's disease proposes that an autoimmune response to type II collagen could induce idiopathic endolymphatic hydrops. This hypothesis is extended to provide a rational explanation for Meniere's attacks.
SchuknechtHF. Pathogenesis and pathology of Meniere's disease [Abstract]. Presented at the Midwinter Research Meeting, Assoc Res Otolaryngol, St Petersburg, Fla, January 1982.
4.
MénièreP. Mémoire sur les lésions de l'oreille interne donnant lieu à des symptômes de congestion cérébrale apoplectiforme. Gaz Med Paris. Series 2, 1861; 16:597.
5.
KitaharaM. Meniere's disease. Kyoto, Japan: Shiga University Press, 1981.
6.
HallpikeCSCairnsH. Observations on the pathology of Meniere's syndrome. Proc R Soc Med1938; 31:1317–36.
7.
BekesyGV. Gross localization of the place of origin of the cochlear microphonics. J Acoust Soc Am1952; 24:399–409.
8.
SmithCALowryOHWuML. The electrolytes of the labyrinthine fluids. Laryngoscope1954; 64:141–53.
9.
TasakiIFernandezC. Modification of cochlear microphonics and action potentials by KCl solution and direct currents. J Neurophysiol1952; 15:497–512.
10.
DohlmanGF. The mechanism of secretion and absorption of endolymph in the vestibular apparatus. Acta Otolaryngol (Stockh)1965; 59:275–88.
11.
SilversteinH. The effects of perfusing the perilymphatic space with artificial endolymph. Ann Otol Rhinol Laryngol1970; 79:754–65.
KimuraRS. Experimental blockage of the endolymphatic duct and sac and its effect on the inner ear of the guinea pig: A study on endolymphatic hydrops. Ann Otol Rhinol Laryngol1967; 76:664–87.
14.
YooTJStuartJMKangAHTownesASTomodaKDixitS. Type II collagen autoimmunity in otosclerosis and Meniere's disease. Science1982; 217:1153–5.
15.
StuartJMPostlethwaiteAETownesASKangAH. Cell-mediated immunity to collagen and collagen α chains in rheumatoid arthritis and other rheumatic diseases. Am J Med1980; 69: 13–8.
16.
FoidartJNAbeSMartinGR. Antibodies to type II collagen in relapsing polychondritis. N Engl J Med1978; 299: 1203–7.
17.
StuartJMPostlethwaiteAEKangAH. Evidence for cell-mediated immunity to collagen in progressive systemic sclerosis. J Lab Clin Med1976; 88:601.
18.
KravisTAhmedABrownTEFulmerJDCrystalRG. Pathogenic mechanisms in pulmonary fibrosis. J Clin Invest1976; 58:1223–32.
TomodaKYooTJ. Type II collagen distribution in the inner ear [Abstract]. Presented at the Midwinter Research Meeting, Assoc Res Otolaryngol, St Petersburg, Fla, January 1983.
21.
WittmaackK. Die entzündlichen Erkrankungen des inneren Ohres. In: HenkeFLubarchO, eds. Handbuch der speziellen pathologischen Anatomie and Histologie. Vol 12. Berlin: Julius Springer, 1926:290–397.
22.
MeyerhoffWLSheaDAGiebinkGS. Experimental pneumococcal otitis media: A histopathologic study. Otolaryngol Head Neck Surg1980; 88:606–12.
23.
NaitoT. Clinical and pathological studies on Meniere's disease. Jpn J Otol Rhinol Laryngol1959; 62:2636–9.
24.
SadamitsuY. Studies on Meniere's disease. IV. Experimental studies. Shikoku Med1963; 19:378–88.
25.
KumagamiHNishidaHDohiK. Experimental labyrinthine lesions through stylomastoid foramen. ORL1976; 38: 334–43.
26.
KimuraRSSchuknechtHFOtaCYJonesDD. Obliteration of the ductus reuniens. Acta Otolaryngol (Stockh)1980; 89: 295–309.
27.
KimuraRS. Experimental pathogenesis of hydrops. Arch Otol Rhinol Laryngol1976; 121:263–75.
28.
KonishiTKelseyE. Cochlear potentials and electrolytes in endolymph in experimentally induced endolymphatic hydrops of guinea pigs. In: RubenRJElberlingCSalomonG, eds. Electrocochleography. Baltimore: University Park Press, 1976:263–75.
29.
LimDJDunnEEJohnsonDLMooreTJ. Trauma of the ear from infrasound. Acta Otolaryngol (Stockh)1982; 94: 213–31.
30.
IshidaTHozawaJKamatoSKimuraN. Labyrinthine reactions in animals sensitized by HRP (horseradish peroxidase). Ear Res (Japan)1981; 12:55–8.
31.
YooTJYazawaYTomodaKFloydR. Type II collagen-induced autoimmune endolymphatic hydrops in guinea pig. Science, 1983; 222:65–7.
32.
TimplRvan der MarkKvan der MarkH. Immunochemistry and immunohistology of collagens. In: ViidikAVuustJ, eds. Biology of collagen. New York: Academic Press, 1980: 211–22.
33.
MichaeliD. Immunochemistry of collagen. In: AtassiMS, ed. Immunochemistry of proteins. New York: Plenum1977: 371–99.
34.
KuhnKGlanvilleRW. Molecular structure and higher organization of different collagen types. In: ViidikAVuustJ, eds. Biology of collagen. New York: Academic Press, 1980:1–14.
35.
TrelstadRLKangAHTooleBPGrossJ. Collagen heterogeneity; high resolution separation of native [α1(I)] α2 and [a1(II)]3 and their component α chains. J Biol Chem1972; 247: 6469–73.
36.
TimplR. Immunological studies on collagen. In: RamechandranGNReddiAH, eds. Biochemistry of collagen. New York: Plenum, 1976:319–75.
37.
NowackHHahnETimplR. Specificity of the antibody response in inbred mice to bovine type I and type II collagen. Immunology1975; 29:621–8.
38.
TrenthamDETownesASKangAH. Autoimmunity to type II collagen: An experimental model of arthritis. J Exp Med1977; 146:857–68.
39.
TrenthamDETownesASKangAHDavidJR. Humoral and cellular sensitivity to collagen in type II collagen-induced arthritis in rats. J Clin Invest1978; 61:89–96.
40.
StuartJMCremerMAKangAHTownesAS. Collagen-induced arthritis in rats: Evaluation of early immunologic events. Arthritis Rheum1979; 22: 1344–51.
41.
CremerMAPitcockJAStuartJMKangAHTownesAS. Auricular chondritis in rats: An experimental model of relapsing polychondritis induced with type II collagen. J Exp Med1981; 154:534–40.
42.
YooTJTomodaKStuartJMKangAHTownesAS. Type II collagen-induced autoimmune otospongiosis. Ann Otol Rhinol Laryngol1983; 92; 2:103–8.
43.
YooTJ. Etiopathogenesis of otosclerosis: A hypothesis. Ann Otol Rhinol Laryngol1984; 93:28–33.
44.
CraigmyleMB. A study of cartilage homografts in rabbits sensitized by a skin homograft from the cartilage donor. Transplant Bull1960; 26: 150–3.
45.
GibsonT. The transplantation of cartilage. J Clin Pathol1967; 20:513–7.
46.
Ortiz-OrtizLWeigleWO. Cellular events in the induction of experimental allergic encephalomyelitis in rats. J Exp Med1976; 144:604–16.
47.
ClagettJAWeigleWO. Role of T and B lymphocytes in the termination of unresponsiveness to autologous thyroglobulin in mice. J Exp Med1974; 139:643–60.
48.
WeigleWO. Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. In: DixonFJKunkelHG, eds. Advances in immunology. Vol 30. New York: Academic Press, 1980:159–273.
49.
ArnoldWMorgensternCMiyamotoH. Morphology and function of the endolymphatic sac. In: VosteenEHSchuknechtHPfaltzCR, eds. Meniere's disease: Pathogenesis, diagnosis and treatment. New York: Georg Thieme Verlag, 1981:110–4.
JahnkeK. Permeability barriers of the inner ear in respect to the Meniere's attack. In: VosteenEHSchuknechtHPfaltzCR, eds. Meniere's disease: Pathogenesis, diagnosis and treatment. New York: Georg Thieme Verlag, 1981:67–74.
52.
SchuknechtHF. Correlation of pathology with symptoms of Meniere's disease. Otolaryngol Clin North Am1968; 1:433–40.
53.
YooTJTomodaKStuartJMKangATownesA. Type II collagen-induced autoimmune sensorineural hearing loss and vestibular dysfunction in rats. Ann Otol Rhinol Laryngol1983; 92:267–71.
54.
MeniereE. Quelques considerations sur la maladie du Meniere. Paris: JB Bailliere et fils, 1880.
55.
KitaharaMTakedaTYazawaYMatsubaraHKitanoH. Experimental study on Meniere's disease. Otolaryngol Head Neck Surg1982; 90:470–81.
56.
WilbrandWFStableJ. Temporal bone in patients with Meniere's disease. In: VosteenEHSchuknechtHPfaltzCR, eds. Meniere's disease: Pathogenesis, diagnosis, and treatment. New York: Georg Thieme Verlag, 1981:131–7.