The histologic appearance of the molded tympanic heterograft developed at the ENT Clinic of the University of Parma, Italy, is investigated with light and electron microscopy. Evaluation of the graft before insertion disclosed a unique structure of interwoven collagen bundles. Examination of grafted tympanic membrane showed a structure closely resembling the normal human tympanic membrane. The fate of the heterologous material and the host reaction to it are discussed in relation to histologic findings.
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References
1.
PattersonME. Experimental tympanic membrane closure with collagen film. Arch Otolaryngol1967; 86: 486–9.
2.
KosoyJSataloffJLaughlinL. Aortic valves in myringoplasty. Arch Otolaryngol1968; 87: 364–7.
ZiniC. Héterogreffes tympaniques. Actas XI Congr Mund ORL (Buenos Aires)1977; 1: 422–5.
7.
ZiniCSannaMBacciuS. La ricostruzione della membrana timpanica mediante eterotrapianti. 1st Congr Soc Ric in Chir, Roma, 1975. Policlinico Sez Chir1976; 83: 653–60.
8.
ZiniCSannaMBacciuS. Héterogreffes tympaniques en tympanoplastie fermée: techniques et resultats. CR LXXIII Congr Franç ORL, Arnette Ed, Paris, 1976; 249–56.
9.
ZiniCSannaMBacciuS. Une methode alternative aux homogreffes: héterogreffes tympaniques moulées. CR LXXV Congr Franç ORL, Arnette Ed, Paris, 1978; 451–6.
10.
ZiniCSannaMBacciuSJemmiG. Cinq années d'experience des héterogreffes tympaniques moulées. CR LXXVI Congr Franç ORL, Arnette Ed, Paris, 1979; 83–8.
11.
ZiniCSannaM. La ricostruzione dell'apparato timpano ossiculare nei bambini. V° Congr Soc Ital ORL Ped, Catania, 1980; 317–38.
12.
ZiniCSheehyJLSannaM. Microsurgery of cholesteatoma of the middle ear. Milano: Libreria Scientifica già Ghedini, 1983.
13.
ZiniCSannaMBacciuS. Audiometric and tympanometric results in closed tympanoplasty using tympanic heterografts. Read at the First International Meeting of the Politzer Society, Davos, Switzerland, 1978.
14.
RosenbergNHendersonJLordGHBothwellJW. An arterial prosthesis of heterologous vascular origin. JAMA1964; 187: 165–7.
15.
RosenbergNMartinezASawyerPNWesolowskiSAPostlewaitRWDillonML. Tanned collagen arterial prosthesis of bovine carotid origin in man. Ann Surg1966; 164: 247–56.
16.
RosenbergNLordGHHendersonJBothwellJWGaughranER. Collagen arterial graft of bovine origin: Seven year observation in the dog. Surgery1970; 67: 951–6.
