It is hypothesized that otosclerosis is an autoimmune disease in response to native type II collagens of cartilage rests associated with globular ossei in the endochondral layer of the otic capsule. To support this hypothesis animal experimental data and human antibody data are shown.
YooTJTomodaKStuartJMKangAHTownesASCremerMA. Type II collagen-induced autoimmune sensorineural hearing loss and vestibular dysfunction in rats. Ann Otol Rhinol Laryngol1983; 92: 267–71.
11.
TomodaKYooTJ. Eustachian tube chondritis and salpingitis induced with type II collagen. Otolaryngol Head Neck Surg (in press).
12.
YooTJKomodaKStuartJKangAHCremerMTownesA. Collagen-induced autoimmune neurosensory hearing loss, vestibular dysfunction, and otosclerosis in rodents. Abstract 61. ARO 5th Midwinter Res Meeting, St Petersburg Beach, Fla, 1982.
13.
RamachandranGNReddiAH, eds. Biochemistry of collagen. New York: Plenum, 1976.
14.
ViidikAVuustJ, eds. Biology of collagen. New York: Academic Press, 1980.
15.
TrenthamDETownesASKangAH. Autoimmunity to type II collagen: An experimental model of arthritis. Exp Med1977; 146: 857–68.
16.
TrenthamDETownesASKangAHDavidJR. Humoral and cellular sensitivity to collagen in type II collagen-induced arthritis in rats. Clin Invest1978; 61: 89–96.
17.
StuartJMCremerMAKangAHTownesAS. Collagen-induced arthritis in rats: Evaluation of early immunologic events. Arthritis Rheum1979; 22: 1344–51.
18.
CremerMAStuartJTownesAS. Kang AH. Collagen-induced polyarthritis in rats: A study of native type II collagen for adjuvent activity. J Immunol1980; 124: 2912–8.
19.
StuartJMPostlethwaiteAETownesASKangAH. Cell-mediated immunity to collagen and collagen α in rheumatoid arthritis and other rheumatic diseases. Am J Med1980; 69: 13–8.
20.
StuartJMTownesASKangAH. The immune response to collagen in type II collagen-induced arthritis in mice. J Clin Invest1982; 69: 673–83.
21.
CremerMAPetcockJAStuartJM. Kang AH, Townes AS. Auricular chondritis in rats: An experimental model of relapsing polychondritis induced with type II collagen. J Exp Med1981; 154: 534–40.
22.
FoidartJMAbeSMartinGR. Antibodies to type II collagen in relapsing polychondritis. N Engl J Med1978; 299: 1203–7.
SteffenCTimplR. Antigenicity of collagen and its application in serological investigation of rheumatoid arthritis sera. Int Arch Allergy Appl Immunol1963; 22: 33–49.
25.
SolingerAMBhatnagerRStoboJD. Cellular, molecular, and genetic characteristics of T cell reactivity to collagen in man. Proc Natl Acad Sci USA1981; 78: 3877–81.
26.
AndroipoulosNAMesteckyJMillerEJBradleyEL. Antibodies to native and denatured collagens in sera of patients with rheumatoid arthritis. Arthritis Rheum1976; 19: 613–7.
27.
KuhnKGlanvilleRW. Molecular structure and higher organization of different collagen types. In: ViidikAVuustJ, eds. Biology of collagen. New York: Academic Press, 1980: 1–14.
28.
YooTJStuartJMKangAHTownesATomodaKDixitS. Type II collagen autoimmunity in otosclerosis and Meniere's disease. Science1982; 217: 1153–5.
29.
YooTJStuartJMKangAHTownesATomodaK. Collagen autoimmunity as a cause of otosclerosis and Meniere's disease. Abstract 121. ARO 5th Midwinter Res Meeting, St Petersburg Beach, Fla, 1982.
30.
StuartJMYooTJKangAHTownesASTomodaKDixitSN. Collagen autoimmunity as cause of otosclerosis. Abstract 1004. Fed Am Soc Exp Biol1982; 41: 441.
31.
BaylinkDJFarleyJR. Isolated and partial purification of a putative coupling factor from human bone. Clin Res1981; 29: 577A.
32.
KuhnKGlanvilleRW. Molecular structure and higher organization of different collagen types. In: ViidikAVuustJ, eds. Biology of collagen. New York: Academic Press1980: 1–14.
33.
TimplRVon der MarkKVon der MarkH. Immunochemistry and immunohistology of collagen. In: ViidikAVuustJ, eds. Biology of collagen. New York: Academic Press, 1980: 211–22.
34.
MichaeliD. Immunochemistry of collagen. In: AtassiMZ, ed. Immunochemistry of proteins. New York: Plenum, 1977: 371–99.
35.
RhodeHHahnETimplR. Radioimmunoassay for aminoterminal procollagen peptides in liver diseases. Fresenius Z Analyt Chem1978; 290: 151–2.
36.
TimplR. Immunological studies on collagen. In: RamachandranGNReddiAH, eds. Biochemistry of collagen. New York: Plenum, 1976: 319–75.
37.
NowackHHahnETimplR. Specificity of the antibody response in inbred mice to bovine type I and type II collagen. Immunology1975; 29: 621–8.
38.
CraigmyleMB. A study of cartilage homografts in rabbits sensitized by a skin homograft from the cartilage donor. Transplant Bull1960; 26: 150–3.
39.
GibsonT. The transplantation of cartilage. J Clin Pathol1967; Suppl 20: 513–7.
40.
Ortiz-OrtizLWeigleWO. Cellular events in the induction of experimental allergic encephalomyelitis in rats. J Exp Med1976; 144: 604–16.
41.
ClagettJAWeigleWO. Role of T and B lymphocytes in the termination of unresponsiveness to autologens thyroglobulin in mice. J Exp Med1974; 139: 643–60.
42.
WeigleWO. Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. In: DixonFJKunkelHG, eds. Advances in immunology. Vol 30. New York: Academic Press, 1980; 159–273.
43.
NowackHHahnETimplR. Specificity of the antibody response in inbred mice to bovine type I and type II collagen. Immunology1975; 29: 621–8.
44.
McDevittHOBodmerWF. Histocompatibility antigens, immune responsiveness and susceptibility to disease. Am J Med1972; 52: 1–8.
45.
StastnyP. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med1978; 298: 869–71.
46.
WayoffMChobautJCRaffauxCBertrandD. Systeme HLA et otospongiose. J Fr Othorhinolaryngol1979; 28: 299–301.
47.
BachFHBachML. Immunologic aspects of the major histocompatibility complex. In: MiddletonJEReedCEEllisEF, eds. Allergy principles and practice. Vol 1. St Louis: CV Mosby Co, 1978: 12–36.