One hundred thirty-six cases of subglottic hemangioma in infants have been reported in the English -language literature; four additional cases are reported here. The clinical presentations, diagnostic work-ups, treatments, and outcomes are analyzed. Twenty-one patients died, 17 of whom underwent autopsy. The histology of the laryngeal pathology from seven of these patients was reviewed by the authors. Possible correlation between the pathological findings and the clinical presentation is made. Approaches to diagnosis and treatment are suggested based on these findings.
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References
1.
MacKenzieM. Essay on growths of the larynx. Philadelphia: Lindsay and Blakeston Co, 1871.
2.
PhillipsJRuhHO. Angioma of the larynx: Especially its relationship to chronic laryngitis. Am J Dis Child1912; 5: 123–30.
3.
LevbargJJ. Intubation for angioma of the larynx in a child ten weeks old. Laryngoscope1918; 28: 867–8.
4.
BiglerJAHolingerPHJohnstonKCSchillerF. Tracheostomy in infancy. Pediatrics1954; 13: 476–85.
5.
BakerDCPenningtonCL. Congenital hemangioma of the larynx. Laryngoscope1956; 66: 696–701.
6.
FergusonCFFlakeCG. Subglottic hemangioma as a cause of respiratory obstruction in infants. Ann Otol Rhinol Laryngol1961; 70: 1095–112.
7.
PierceMK. Subglottic hemangiomas in infants — a presumptive clinical test for diagnosis. Ann Otol Rhinol Laryngol1962; 71: 1057–62.
8.
LittlerER. Asphyxia due to hemangioma in the trachea. J Thorac Cardiovasc Surg1963; 45: 552–8.
9.
CohenSRWangC. Steroid treatment of hemangioma of the head and neck in children. Ann Otol Rhinol Laryngol1972; 81: 584–90.
10.
NewGBClarkCM. Angiomas of the larynx: Report of three cases. Ann Otol Rhinol Laryngol1919; 28: 1025–37.
11.
RyersonGS. Angioma of the larynx. Can Med Assoc J1912; 2: 3.
12.
SweetserTH. Hemangioma of the larynx. Laryngoscope1921; 31: 797–806.
13.
SuehsDWHerbutPA. Hemangioma of the larynx in infants. Arch Otolaryngol1940; 32: 783–9.
14.
FergusonGB. Hemangioma of the adult and infant larynx. Arch Otolaryngol1944; 40: 189–95.
15.
KasabachHHDonlanCP. Radiotherapy of hemangioma of the larynx in infants. J Pediatr1945; 26: 374–8.
16.
SharpHS. Hemangioma of the trachea in an infant, successful removal. J Laryngol Otol1949; 63: 413–4.
17.
CampbellJSWiglesworthFWLataroccaRWoldeH. Congenital subglottic hemangiomas of the larynx and trachea in infants. Pediatrics1958; 22: 727–37.
HorwitzJDEmanuelBLiebermanADAronowJ. Subglottic hemangioma: A cause of upper respiratory obstruction in the infant. Ill Med J1963; 123: 255–6.
39.
TefftM. The radiotherapeutic management of subglottic hemangioma in children. Radiology1966; 86: 207–14.
40.
SchecterGLBillerHF. The limitations of corticosteroids and cryotherapy for subglottic hemangioma. Trans Am Acad Ophthalmol Otolaryngol1972; 76: 1360–2.
41.
CalcaterraTC. An evaluation of the treatment of subglottic hemangioma. Laryngoscope1968; 78: 1956–64.
42.
GordonLP. Case for diagnosis: Subglottic hemangioma and cerebral edema. Mil Med1979; 144: 659–60.
43.
FeuersteinSS. Subglottic hemangioma in infants. Laryngoscope1973; 83: 466–75.
44.
KarjaJPalvaAJokinenK. Cryotherapy in the treatment of subglottic hemangioma in infants. Acta Otolaryngol (Stockh) (suppl)1979; 360: 58–60.
45.
SimpsonGTHealyGBMcGillTStrongMS. Benign tumors and lesions of the larynx in children, surgical excision by CO2 laser. Ann Otol Rhinol Laryngol1979; 88: 479–86.
46.
HealyGBMcGillT. Treatment of subglottic hemangiomas with CO2 laser. Laryngoscope1980; 90: 809–13.