During a 2-year period ending December 1978, we encountered 27 cases of otitis media secondary to ampicillin-resistant Hemophilus influenzae. This represents 19% of the 139 Hemophilus isolates obtained by tympanocentesis. In agreement with data from Huntsville, Alabama, Boston, and Pittsburgh, we estimate that as of 1978, approximately 4% of all cases of acute otitis media are caused by this pathogen.
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