In vivo studies of different aspects of bone resorption in human cholesteatomas are described in the immunodeficient “nude” mice. Cholesteatoma membranes were transplanted into the middle ear cavities of the mice. After 21–28 days, growth of cholesteatoma tissue could be demonstrated in 8 of 13 animals. In 7 of these 8 animals bone resorption of the labyrinthine wall and ossicles could be demonstrated; resorption with acute inflammation was found in only two animals. The cellular mechanism in relation to bone resorption is discussed.
Get full access to this article
View all access options for this article.
References
1.
SadéJHalevyA. The aetiology of bone destruction in chronic otitis media. J Laryngol Otol1974; 88: 139–43.
2.
ThomsenJBretlauPKristensenHK. Bone resorption in chronic otitis media: A light microscopical and histochemical investigation of acid phosphatase activity. Acta Otolaryngol (Stoekh)1975; 79: 400–4.
3.
ThomsenJBretlauPJorgensenMB. Bone resorption in chronic otitis media: The role of cholesteatoma, a must or an adjunct?Clin Otolaryngol1981; 6: 179–86.
FriedmannI. Epidermoid cholesteatoma and cholesterol granuloma: Experimental and human. Ann Otol Rhinol Laryngol1959; 68: 57–79.
6.
FriedmannI. The pathology of the ear. Oxford: Blackwell, 1974.
7.
RüediL. Cholesteatoma formation in the middle ear in animal experiments. Acta Otolaryngol (Stoekh)1959; 50: 233–42.
8.
FriedmannI. The pathology of epidermoid cholesteatoma: Human and experimental In: McCabeBFSadéJAbramsonM, eds. Cholesteatoma: First international conference. Birmingham: Aesculapius Publishing Co, 1977: 10–22.
9.
SteinbachEGrüningerG. Experimental production of cholesteatoma in rabbits by using non-irritants (skin tolerants). J Laryngol Otol1980; 94: 269–79.
10.
BretlauPDabelsteenEHolmstrupP. A method for studying cholesteatomas in vivo: With special attention to epithelial-mesenchymal interaction. Clin Otolaryngol1981; 6: 81–5.
11.
GantzBClanceyCAbramsonM. Decalcification factors in granulation tissue and ear canal skin. In: McCabeBFSadéJAbramsonM, eds. Cholesteatoma: First international conference. Birmingham: Aesculapius Publishing Co, 1977: 167–9.
12.
BernsteinJHausmannEWrightJ. Middle ear disease release of soluble factor (S) stimulating bone resorption. In: McCabeBFSadéJAbramsonM, eds. Cholesteatoma: First international conference. Birmingham: Aesculapius Publishing Co, 1977: 152–61.
13.
AbramsonM. Collagenolytic activity in middle ear cholesteatoma. Ann Otol Rhinol Laryngol1969; 78: 112–24.
14.
AbramsonMGrossJ. Further studies on a collagenase in middle ear cholesteatoma. Ann Otol Rhinol Laryngol1971; 80: 177–85.
15.
ThomsenJBretlauPJorgensenMBKristensenHK. Bone resorption in chronic otitis media. In: McCabeBFSadéJAbramsonM, eds. Cholesteatoma: First international conference. Birmingham: Aesculapius Publishing Co, 1977: 136–48.
16.
GantzBFMaynardJBumstedRMHuangCCAbramsonM. Bone resorption in chronic otitis media. Ann Otol Rhinol Laryngol1979; 88: 693–700.
17.
KraneSMDayerJMColdringSR. Aspects of bone resorption. In: McCabeBFSadéJAbramsonM, eds. Cholesteatoma: First international conference. Birmingham: Aesculapius Publishing Co, 1977: 102–14.
AbramsonMAsarchRGLittonWB. Experimental aural cholesteatoma causing bone resorption. Ann Otol Rhinol Laryngol1975; 84: 425–32.
23.
AbramsonMHuangCC. Cholesteatoma and bone resorption. In: McCabeBFSadéJAbramsonM, eds. Cholesteatoma: First international conference. Birmingham: Aesculapius Publishing Co, 1977: 162–6.
24.
DayerJMRusselRGKraneSM. Collagenase production by rheumatoid synovial cells: Stimulation by a human lymphocyte factor. Science1977; 195: 181–3.
