Rubella, cytomegalovirus, mumps, and rubeola viruses cause deafness in man and are believed to reach the inner ear through viremic spread. Although several experimental studies of viral infection of the inner ear have been described, all require the virus inoculum to reach the labyrinth directly rather than through hematogenous spread. In this model, reovirus, type 3, infected the cell bodies of cochlear and vestibular ganglia of infant hamsters following a viremia induced by intraperitoneal inoculation. This model provides the first experimental evidence for viremic spread to the inner ear.
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