Cefaclor, a semisynthetic cephalosporin antibiotic for oral use, was studied by 62 clinical investigators in six countries in 3,084 adult and pediatric patients. The pooled data reveal that satisfactory clinical responses were obtained in 96% of the streptococcal pharyngitis cases, 93% of the cases of otitis media, and 97% of skin infections. Administration of this antibiotic was associated with a low incidence of adverse reactions, including 73 gastrointestinal and 34 hypersensitivity reactions. Of particular clinical interest were the outstanding results obtained in the treatment of otitis media.
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