Data are presented from pharmacologic evaluations of major oral antibiotics used in treatment of acute otitis media and tonsillopharyngitis in children. Information is included on serum and middle ear specimens obtained almost simultaneously following administration of many of these antibiotics. Discussion covers ampicillin and amoxicillin, penicillin G and V, erythromycin estolate, erythromycin ethylsuccinate and the orally administered cephalosporins.
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