Abstract
Esophageal cancer, which accounts for 21 % of all cancer deaths in China, has been the subject of epidemiology studies in the three areas of the country where the disease is most prevalent. In the area of the highest mortality rate, the first field research unit was established to study cancer in high-risk areas. The investigations of this unit for the last 20 years are discussed, including the design and implementation of the studies. The geographic, dietary and cultural factors in the etiology of esophageal cancer are examined. The results of the studies and the clinical applications are explored.
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