The cross-sectional areas of brainstem auditory neurons were measured in a postnatal developmental series of mice. There is no demonstrable neuronal growth between days 1 and 3. Between days 3 and 12 the neuronal somas grow rapidly to their adult size. Most of this growth occurs prior to any cochlear physiological activity and all of it occurs before cochlear maturation. Most brainstem auditory neurons of 45-day-old mice postnatally deprived of sound or with conductive losses are of a size comparable to normal nine-day-old mice.
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References
1.
MikaelianDRubenRJ. Development of hearing in the normal CBA-J mouse. Acta Otolaryngol (Stockh) 1965; 59: 451–61.
2.
WeibelER. Zur Kenntnis der Differenzierungsvorgänge im Epithel des Ductus cochlearis. Acta Anat (Basel)1957; 29: 53–90.
3.
KikuchiKHildingD. The development of the organ of Corti in the mouse. Acta Otolaryngol (Stockh) 1965; 60: 207–22.
4.
SchmidtRSFernandezC. Development of mammalian endocochlear potential. J Exp Zool1963; 153: 227–35.
5.
MlonyeniM. The late stages of the development of the primary cochlear nuclei in mice. Brain Res1967; 4: 334–44.
6.
EhretG. Development of absolute auditory thresholds in the house mouse (Mus musculus). J Am Audiol Soc1976; 1: 179–84.
7.
EhretG. Postnatal development in the acoustic system of the house mouse in the light of developing masked thresholds. J Acoust Soc Am1977; 62: 143–8.
WebsterDBWebsterM. Effects of neonatal conductive hearing loss on brainstem auditory nuclei. Ann Otol Rhinol Laryngol1979; 88: 684–7.
10.
WebsterDB. The ear apparatus of the kangaroo rat, Dipodomys. Am J Anat1961; 108: 123–48.
11.
FernstromRC. A durable Nissl stain for frozen and paraffin sections. Stain Technol1958; 33: 175–6.
12.
OsenKK. Cytoarchitecture of the cochlear nuclei in the cat. J Comp Neurol1969; 136: 453–84.
13.
AlfordBRRubenRJ. Physiological, behavioral and anatomical correlates of the development of hearing in the mouse. Ann Otol Rhinol Laryngol1963; 72: 237–46.
