Combined therapy, consisting of 5000 rads delivered in five weeks followed by total laryngectomy ± radical neck dissection, was compared with treatment by irradiation (6000–7000 rads) with surgical salvage when clinically possible for radiation failure. Patients were categorized according to site of primary cancer (glottic, supraglottic and pyriform sinus) and staged (T, N, M). Survival was equally good in the two programs for glottic and supraglottic lesions, N0 or N1. The combined treatment program was judged superior for supraglottic and pyriform sinus lesions, N2 or N3.
Get full access to this article
View all access options for this article.
References
1.
BillerHFOguraJHDavisWH: Planned preoperative irradiation for carcinoma of the larynx and laryngopharynx treated by total and partial laryngectomy. Laryngoscope79: 1387–1395, 1969.
2.
FlynnMBJesseRHLindbergRD: Surgery and irradiation in the treatment of squamous cell cancer of the supraglottic larynx. Am J Surg124: 477–481, 1972.
3.
GoldmanJLSilverstoneSMRoffmanJD: High dosage preoperative radiation and surgery for carcinoma of the larynx and laryngopharynx — A 14-year program. Laryngoscope82: 1869–1882, 1972.
4.
BloedornFG: Radiation and surgery, in BuschkeF (ed): Advances in Radiation Therapy, vol II. New York, Grune and Stratton, 1962, pp 114–136.
5.
JesseRHLindbergRD: The efficacy of combining radiation therapy with a surgical procedure in patients with cervical metastasis from squamous cancer of the oropharynx and hypopharynx. Cancer35: 1163–1166, 1975.
6.
StrongEWHenschkeUKNicksonJJ: Preoperative x-ray therapy as an adjunct to radical neck dissection. Cancer19: 1509–1516, 1966.
7.
LevittSHBeachleyMCZimbergY: Combination of preoperative irradiation and surgery in the treatment of cancer of the oropharynx, hypopharynx, and larynx. Cancer27: 759–767, 1971.
8.
WangCCSchulzMDMillerD: Combined radiation therapy and surgery for carcinoma of the supraglottis and pyriform sinus. Laryngoscope82: 1883–1890, 1972.
9.
CummingsCWJohnsonJChungCT: Complications of laryngectomy and neck dissection following planned preoperative radiotherapy. Ann Otol Rhinol Laryngol86: 745–750, 1977.
10.
Manual for Staging of Cancer 1977.Chicago, American Joint Committee for Cancer Staging and End Results Reporting, 1977.
11.
FletcherGH: Elective irradiation of subclinical disease in cancers of the head and neck. Cancer29: 1450–1454, 1972.
12.
GoldmanJLRoffmanJDZakFG: High dosage preoperative radiation and surgery for carcinoma of the larynx and laryngopharynx. Ann Otol Rhinol Laryngol81: 488–495, 1972.
13.
JesseRHFletcherGH: Treatment of the neck in patients with squamous cell carcinoma of the head and neck. Cancer39: 868–872, 1977.
14.
McGavranMHOguraJHPowersWE: Small-dose preoperative radiation therapy. A preliminary report based on some histological observations of thirty resected epidermoid carcinomas of the upper respiratory and digestive tracts. Radiology83: 509–519, 1964.
15.
PowersWE: Radiation biologic considerations and practical investigations in preoperative radiation therapy. J Can Assoc Radiol16: 217–225, 1965.
