An overview of the developing laryngeal epithelium has been presented to establish the norm. The sequential relationships of the formation of the protective laryngeal covering, cellular and glandular, have been reviewed. The topographical distribution of the epithelial elements in the human larynx are illustrated in the adult and contrasted in the child. Unique and previously undescribed cellular ultrastructure and transition areas have been identified. Biological integration of form and function is again well illustrated in the epithelium of the human larynx.
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References
1.
StrickerS: Manual of Human and Comparative Histology.PowerH (trans), London, New Sydenham Society, 1872, p 38.
2.
EpsteinSS: A stripping technique for the examination of the total epithelial surface of the larynx. J Pathol Bacteriol75: 472–473, 1958.
3.
TuckerGFJr.: A histological method for the study of the spread within the larynx of carcinoma. Ann Otol Rhinol Laryngol70: 910–921, 1961.
4.
TuckerGFJr.: The anatomy of laryngeal cancer. Can J Otolaryngol3: 413–431, 1974.
5.
ZilliacusW: Die Ausbreitung der verschiedenen Epithelarten im menschlichen Kehlkopfe und eine neue Methode, dieselbe festzustellen. Anat Anz26: 25–30, 1905.
6.
StellPMGregoryIWattJ: Techniques for demonstrating the epithelial lining of the larynx. J Laryngol Otol38: 589–594, 1972.
7.
HoppES: The development of the epithelium of the larynx. Laryngoscope65: 475–499, 1955.
8.
KanthackAA: Studien uber die Histologie der Larynxschleimhaut. Arch Pathol Anat118: 137–147; 273–294; 326–342, 1889.
9.
HeymannR: Beitrage z kenntniss d epithels u d drusen d menschliches kehlkopfes im ges u krank zustande. Virchows Arch188: 320–348, 1889.
10.
FrazerJE: The development of the larynx. J Anat Physiol (Paris) 44: 156–191, 1910.
11.
HeymannJ: Die Histologie der Schleimhaut des Kehlkopfes und der Luftrohre. Handb Laryngol Rhinol: 1: 134–164,1898.
12.
SoulieABardierE: Recherches sur le developpement du larynx chez l'homme. J Anat Physiol (Paris) 43: 137–240, 1907.
13.
KalliusE: Beitrage zur entwickelungsgeschichte des kehlkopfes. Anat9: 303–363, 1897.
14.
ShikinamiJ: Detailed form of the Wolffian body in human embryos of the first eight weeks. Contr Embryol Carneg Instn18: 46–61, 1926.
15.
TuckerJATuckerGF: Some aspects of fetal laryngeal development. Ann Otol Rhinol Laryngol84: 49–55, 1975.
16.
TuckerJAO'RahillyR: Observations on the embryology of the human larynx. Ann Otol Rhinol Laryngol81: 520–523, 1972.
17.
O'RahillyRTuckerJA: The early development of the larynx in staged human embryos. Part 1: Embryos of the first five weeks (to Stage 15). Ann Otol Rhinol Laryngol (Suppl 7) 82: 3–27, 1973.
18.
WalanderA: Prenatal development of the epithelial primordium of the larynx in the rat. Acta Anat, Suppl 13 (Suppl 2 ad vol 10): 1–140, 1950.
19.
TuckerGFSmithHR: A histological demonstration of the development of laryngeal connective tissue compartments. Trans Am Acad Ophthalmol Otolaryngol66: 308–318, 1962.
20.
PattenBM: Human Embryology.New York, McGraw-Hill, 1968.
21.
TuckerGF: Human Larynx Coronal Section Atlas.Washington, DC, Armed Forces Institute of Pathology, 1971.
22.
HollidayJA: Light and electron microscopy of the epithelium of the human true vocal cord. Laryngoscope81: 1596–1601, 1971.
23.
SugárJ: An electron microscopic study of early invasive growth in human skin tumors and laryngeal carcinoma. Eur J Cancer4: 33–38, 1968.
24.
SugárJFaragóL: Ultrastructure of laryngeal precanceroses. Acta Otolaryngol (Stockh)62: 319–332, 1966.
25.
RhodinJDalhamnT: Electron microscopy of the tracheal ciliated mucosa in rat. Z Zellforsch Mikroskip Anat44: 345–412, 1956.
26.
HildingDAHildingAC: Ultrastructure of tracheal cilia and cells during regeneration. Ann Otol Rhinol Laryngol75: 281–294, 1966.
27.
BarberVCBoydeA: Scanning electron microscopic studies of cilia. Z Zellforsch Mikrosk Anat84: 269–284, 1968.
28.
BiondiSBiondi-ZappalaM: Surface of laryngeal mucosa seen through the scanning electron microscope. Folia Phoniatr26: 241–248, 1974.
29.
FriedmannIBirdES: Ciliary structure, ciliogenesis, microvilli. Electron microscopy of the mucosa of the upper respiratory tract. Laryngoscope81: 1852–1868, 1971.
30.
DulfanoMJ, (ed): Sputum; Fundamentals and Clinical Pathology.Springfield Ill, C C Thomas, 1973.
31.
FawcettDWPorterKR: A study of the fine structures of ciliated epithelia. J Morphol94: 221–281, 1954.
32.
FawcettD: The Cell.Philadelphia, Pa, Saunders, 1966.
33.
SatirP: How cilia move. Sci Am231 (4):44–52, 1974.
