The pattern of terminal mitosis in mouse otocyst observed by Ruben led him to postulate the existence of a growth zone at the junction of saccular and cochlear primordia. With the use of colchicine, an antimitotic drug, a localized zone of mitotic activity has been demonstrated at this predicted site.
Get full access to this article
View all access options for this article.
References
1.
FeinendegenLE: Tritium labeled molecules in biology and medicine.New York, Academic Press, 1967
2.
RubenRJ: Development of the inner ear of the mouse: A radioautographic study of terminal mitosis. Acta Otolaryngol (Stockh) [Suppl] 220, 1967
3.
DeyssonA: Antimitotic substances. Int Rev Cytol24: 99–148, 1968
4.
DustinPJr: New aspects of the pharmacology of antimitotic agents. Pharmacol Rev115: 449–480, 1963
5.
MorrisWT: In vivo studies of the optimum time for the action of colchicine on mouse lymphoid tissue. Exp Cell Res48: 209–212, 1967
6.
KleinfeldRGSiskenJE: Morphological and kinetic aspects of mitotic arrest by and recovery from colcemid. J Cell Biol31: 369–379, 1966
7.
SherAE: The embryonic and postnatal development of the inner ear of the mouse. Acta Otolaryngol (Stockh) [Suppl] 285, 1971
8.
CarpentieriUWilliamsJPA: Stathmokinetic agents and the mitotic index in embryo and adult rats. Curr Mod Biol2: 4–6, 1968
9.
WilliamsJPACarpentieriU: The differential response of embryonic and adult rats to demecolin. Life Sci II6: 2313–2620, 1967
10.
RubenRJVan de WaterTPoreskyA: Cell kinetics of the 11 and 12 day mouse otocysts. Laryngoscope81: 1708–1718, 1971
