A brief review of the literature from otorhinolaryngology and the basic sciences shows the existence and role of nasal-cardiopulmonary reflexes in animals and man There is ample evidence that odors, fluids and mechanical stimulation of the nasal mucosa will induce changes in the lungs and cardiovascular system. The proposition that nasal obstruction also produces cardiopulmonary changes is briefly reviewed. The suggestion is made that one of the functions of the nose is to act as an expiratory brake. The removal of this brake could result in changes in laryngeal resistance that lead to poor ventilation.
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References
1.
OguraJHTogawaK.DammkoehlerR: Nasal obstruction and the mechanics of breathing. Arch Otolaryngol83: 135–150, 1966
2.
UnnoRNelsonJROguraJH: The effect of nasal obstruction on pulmonary, airway and tissue resistance. Laryngoscope78: 1119–1139, 1968
3.
OhnishiTOguraJH: Partioning of pulmonary resistance in the dog. Laryngoscope79: 1847–1878, 1969
4.
OguraJHHarveyJE: Nasopulmonary mechanics — experimental evidence of the influence of the upper airway upon the lower. Acta Otolaryngol (Stockh) 71: 123–132, 1971
5.
KrajinaZHarveyJEOguraJH: Experimental vasomotor rhinitis (in the dog). Laryngoscope82: 1068–1073, 1972
6.
OguraJHSuemitsuMNelsonJR: Relationship between pulmonary resistance and changes in arterial blood gas tension in dogs with nasal obstruction and partial laryngeal obstruction. Ann Otol Rhinol Laryngol82: 668–683, 1973
7.
WhickerJHKernEB: The nasopulmonary reflex in the awake animal. Ann Otol Rhinol Laryngol82: 355–358, 1973
8.
WhickerJHKernEB: Effect of denervation of nasal mucosa on pulmonary mechanics. Ann Otol Rhinol Laryngol82: 724–728, 1973
9.
KratschmerF quoted by Allen WF: Effect on respiration, blood pressure and carotid pulse of various inhaled and insufflated vapors when stimulating one cranial nerve and various combinations of cranial nerves. Am J Physiol87: 319–325, 1928
10.
AllenWF: Effect of various inhaled vapors on respiration and blood pressure in anesthetized, unanesthetized, sleeping and anosmic subjects. Am J Physiol88: 620–632, 1929
11.
TuckerD: Olfactory, vomeronasal and trigeminal receptor responses to odorants, in ZottermanY (ed): Olfaction and Taste, Vol 1. New York, Pergamon Press, 1963, pp 45–69
12.
TuckerD: Nonolfactory responses from the nasal cavity: Jacobson's organ and the trigeminal system, in BeidlerLM (ed): Handbook of Sensory Physiology IV, New York, Springer-Verlag, 1971, pp 151–177
13.
ButVIKlimova-CherkasovaVI: The study of afferentation from the upper respiratory tract. Bull Eksper Biol Med64: 13–16, 1967
14.
von SkramlikE: Die Physiologie des Luftwegs. Hnbk Norm Pathol Physiol Atmung.Berlin, Springer-Verlag, 1925, pp 128–189
15.
AllenWF: A comparative study of the olfactory and trigeminal reflexes elicited by various vapors in different mammals. J Wash Acad Sci26: 466–473, 1936
16.
RamosJG: On the integration of respiratory movements. III. The fifth nerve afferents. Acta Physiol Lat Am10: 104–113, 1960
17.
StoneHCarregalEJAWilliamsB: The olfactory-trigeminal response to odorants. Life Sci5: 2195–2201, 1966
18.
Szerda-PrzestaszewskaMWiddicombeJG: Reflex effects of chemical irritation of the upper airways on the laryngeal lumen in cats. Respir Physiol18: 107–115, 1973
19.
McRitchieRJWhiteSW: Role of the trigeminal, olfactory carotid sinus and aortice-nerves in the respiratory and circulatory response to nasal inhalation of cigarette smoke and other irritants in the rabbit. Aust J Exp Biol Med Sci52: 127–140, 1974
20.
WhiteSWMcRitchieRJFranklinDL: Autonomic cardiovascular effects of nasal inhalation of cigarette smoke in the rabbit. Aust J Exp Biol Med Sci52: 111–126, 1974
21.
GreenJDdeGrootJSutinJ: Trigeminal bulbar reflex pathways. Am J Physiol189: 384–388, 1957
22.
JamesJE AngelldeB DalyM: Reflex respiratory, cardiovascular effects of stimulation of receptors in the nose of the dog. J Physiol (Lond)220: 673–696, 1972
GoodenBAStoneHLYoungS: Cardiac responses to snout immersion in trained dogs. J Physiol (Lond)242: 405–414, 1974
25.
DykesRW: Factors related to the dive reflex in harbor seals: respiration, immersion bradycardia, and lability of the heart rate. Can J Physiol Pharmacol52: 248–258, 1974
26.
FreemanWJ: Adenoid hypertrophy, cyanosis and cor pulmonale in children with congenital heart disease. Laryngoscope83: 238–249, 1973
27.
ClairmontAAHartNJRookerDW: Upper airway obstruction from hypertrophied tonsils and adenoids complicating ventricular septal defect. JAMA, to be published
28.
CassisiNJBillerHFOguraJH: Changes in arterial oxygen tension and pulmonary mechanics with the use of posterior packing in epistaxis: a preliminary report. Laryngoscope81: 1261–1266, 1971
29.
CookTAKomornRM: Statistical analysis of the alterations of blood gases produced by nasal packing. Laryngoscope83: 1802–1809, 1973
30.
KurilinIABondarenkoNAFedunNF: The state of the respiratory and olfactory functions of the nose and the gaseous composition of the blood in bending of the nasal septum. Vestn Otorinolaringol33: 84–86, 1971
31.
StranskyA.Szereda-PrzestaszewskaMWiddicombeJG: The effects of lung reflexes on laryngeal resistance and motorneurone discharge. J Physiol (Lond)231: 417–438, 1973
32.
ChesterEHOstranderLEFranckJB: Influence of breathing rate on airway resistance and compliance measurements. Respir Physiol20: 337–351, 1974
33.
BartlettDRemmersJEGautierH: Laryngeal regulation of respiratory airflow. Respir Physiol18: 194–204, 1973
34.
GautierHRemmersJEBartlettD: Control of the duration of expiration. Respir Physiol18: 205–221, 1973
