Tumor antigens have been isolated from nine epidermoid carcinomas of the head and neck. The most strongly reactive antigens have a molecular weight of ≃ 25,000–50,000 daltons, though other antigens weighing ≃ 120,000–400,000 daltons were noted in six of the tumors. The most strongly reactive antigens from three of the tumors were further purified by isoelectric focusing. Each of these antigens had a pI between 8.36 and 8.40. The cross reactivity of these antigens will be studied next. It is hoped that the purified tumor antigen will be useful in the development of an immunodetection system for epidermoid carcinoma.
Get full access to this article
View all access options for this article.
References
1.
KolbJPPouponMFLespinatsG: Tumor-associated antigen (TAA) and antibodies in the serum of BALB/c mice with plasmacytomas. J Natl Cancer Inst52: 723–727, 1974.
2.
JonesDBMooreM: Antigens of tumours induced by naturally occurring murine sarcoma virus (MSV-FBJ). I. Detection of group and type specific antigens by complement fixation. Br J Cancer29: 21–30, 1974.
3.
BystrynJCSchenkeinIBaurS: Partial isolation and characterization of antigens associated with murine melanoma. J Natl Cancer Inst52: 1263–1269, 1974.
4.
BaldwinRWGlavesDHarrisJR: Tumor specific antigens associated with aminozo-dye induced rat hepatomas. Transplant Proc3: 1189–1190, 1971.
5.
LewisMG: Proceedings: Tumor specific antigens in melanoma. Proc Natl Cancer Conf7: 77–83, 1973.
6.
NordquistRE: Specific antigens in human alveolar carcinoma. Cancer Res33: 1790–1795, 1973.
7.
EdynakEMHirschautYOldLJ: Antigens of human breast cancer. Proc Am Assoc Cancer Res12: 75, 1971.
8.
BillingsRTerasakiPI: Human leukemia antigen. II. Purification. J Natl Cancer Inst53: 1639–1643, 1974.
9.
FoleyEJ: Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin. Cancer Res13: 835, 1963.
10.
PrehnRTMainJM: Immunity to methylcholanthrene-induced sarcomas. J Natl Cancer Inst18: 769, 1957.
11.
AnkerstJSteelGSjogrenHO: Cross-reacting tumor-associated antigens of adenovirus type 9-induced fibroadenomas and a chemically induced mammary carcinoma in rats. Cancer Res34: 1794, 1974.
12.
SteelGSjogrenHO: Cross-reacting tumor-specific transplantation antigens in chemically induced rat colon carcinomas. Cancer Res34: 1801, 1974.
13.
HellstromIHellstromKESjogrenHO: Demonstration of cell-mediated immunity to human neoplasms of various histological types. Int J Cancer7: 1, 1971.
14.
KennedyJT: A Search for Common Tumor Specific Antigen and Serum Blocking Factor in Head and Neck Epidermoid Carcinomas, thesis. University of Iowa, Iowa City, 1973.
15.
GoldPFreedmanSO: Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med121: 439, 1965.
16.
TatarinovYS: Content of embryo-specific alpha-globulin in fetal and neonatal sera and sera from adult humans with primary carcinoma. Fed Proc (Transl Suppl) 25: 344, 1966.
17.
HenleWHenleGHoH: Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms and control groups. J Natl Cancer Inst44: 225–231, 1970.
18.
HenleWHoHCHenleG: Antibodies to Epstein-Barr virus related antigens in nasopharyngeal carcinoma. Comparison of active cases with long term survivors. J Natl Cancer Inst51: 361, 1973.
19.
HollinsheadACChretienPBRawlsWE: Antibodies to herpesvirus non-virion antigens in squamous carcinomas. Science182: 713, 1973.
20.
SlimowskaVKawiakJ: Liberation of cell surface material by the insoluble trypsin derivative. Acta Biochim Pol20: 113–118, 1973.
21.
HerbermanRB: Delayed hypersensitivity skin reaction to antigens on human tumors. Cancer34: 1469–1473, 1974.
