The evolution of tympanic membrane grafting over the past 20 years has been based on biologic tissues of mesodermal origin which contain a collagen matrix. The dominant theme of this evolution has been the modification of these collagen membranes by physical and chemical agents to achieve a more ideal graft. The graft material and the operation should be suited to specific problems. Current operative techniques and graft materials are discussed. It is believed that there will be continued modification and manipulation of collagen in the future to achieve a more ideal graft for tympanic membrane restoration.
MarquetJ: Reconstructive micro-surgery of the eardrum by means of a tympanic membrane homograft. Acta Otolaryngol (Stockh) 62: 459–464, 1966.
3.
GlasscockMEIIIHouseWF: Homograft reconstruction of the middle ear: A preliminary report. Laryngoscope78: 1219–1225, 1968.
4.
PerkinsR: Human homograft otologic tissue transplantation: buffered formaldehyde preparation. Trans Am Acad Ophthalmol Otolaryngol74: 278–282, 1970.
5.
FurthmayrHTimplR: Structural requirements of antigenic determinants in the aminoterminal region of the rat collagen oc 2 chain. Biochem Biophys Res Commun47: 944–950, 1972.
6.
BrunnerHDichtlMSteffenC: Immunogenitat und Spezifitat von chromstabilisiertem Kalbskollagen. Z Immunitaetsforsch142: 460–470, 1971.
7.
JansenC: Heterologous tympanoplasty. Trans Am Acad Ophthalmol Otolaryngol77: 111–116, 1973.
8.
PerkinsR: Formaldehyde formed autogenous fascia graft tympanoplasty. Presented at the Academy of Ophthalmology and Otolaryngology, Dallas, Texas, Oct. 9, 1974. To be published.
9.
HoughJV: Tympanoplasty. Trans Am Acad Ophthalmol Otolaryngol. CETV-OTO, OTO-3, Vol. 1.
10.
PerkinsR: Otologic homograft indications, techniques, and anatomic and functional results. Trans Am Acad Ophthalmol and Otolaryngol80: 41–46, 1975.
