Aminooxyacetic acid (AOAA; 1 mM) when perfused through the scala tympani of guinea pigs produced a biphasic reduction in the endocochlear potential, together with a shift in the input-output functions of the cochlear microphonics and the compound action potential of the cochlear nerve. Since the ionic (Na+, K+) content of the scala media was not altered, it appears that such changes did not underlie the reduction recorded in the endocochlear potential. The negative direct current potential recorded in the organ of Corti did not appear to be affected by the drug. Attempts to antagonize the effects of AOAA with pyridoxine failed.
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References
1.
BobbinRPGonzalesGGuthPS: Effects of aminooxyacetic acid on cochlear potentials and the Preyer reflex. Nature223: 70–71, 1969.
2.
BobbinRPGuthPS: Evidence that gammaaminobutyric acid is not the inhibitory transmitter at the crossed olivocochlear nerve-hair cell junction. Neuropharmacology9: 567–574, 1970.
3.
RubinsteinMKRobertsE: Return of 7-aminobutyrate transaminase activity in mouse brain after inhibition by aminooxyacetic acid: Chemical and histochemical observations. Biochem Pharmacol16: 1138–1139, 1967.
4.
BobbinRPGondraM: Effect of intravenous aminooxyacetic acid on guinea pig cochlear potentials. Neuropharmacology12: 1005–1007, 1973.
5.
TasakiISpyropoulosCS: Stria vascularis as source of endocochlear potential. J Neurophysiol22: 149–155, 1959.
6.
HottaSS: Oxidative metabolism of isolated brain mitochondria: Changes caused by aminooxyacetate. Arch Biochem Biophys127: 132–139, 1968.
7.
HottaSSLevinsonBS: The effect of aminooxyacetate on the metabolism of glucose and glutamate by homogenates of guinea pig cerebral hemispheres. Toxicol Appl Pharmacol16: 154–165, 1970.
8.
TasakiIDavisHLegouixIP: The space time pattern of the cochlear microphonics (guinea pigs) as recorded by differential electrodes. J Acoust Soc Am45: 502–519, 1952.
9.
BobbinRPKonishiT: Action of cholinergic and anticholinergic drugs at the crossed olivocochlear bundle-hair cell junction. Acta Otolaryngol (Stockh) 77: 56–65, 1974.
10.
MendelsohnMKonishiT: The effect of local anoxia on the cation content of the endolymph. Ann Otol Rhinol Laryngol78: 65–75, 1969.
11.
KonishiTKelseyE: Effect of potassium deficiency on cochlear potentials and cation contents of the endolymph. Acta Otolaryngol (Stockh) 76: 410–418, 1973.
12.
KonishiRMendelsohnM: Effect of Ouabain on cochlear potentials and endolymph composition in guinea pigs. Acta Otolaryngol (Stockh) 69: 129–199, 1970.
13.
BobbinRPGondraMI: Source of negative potentials in the organ of Corti. J Acoust Soc Am55: S76, 1974.
14.
HonrubiaVWardPH: Dependence of the cochlear microphonics and the summating potential on the endocochlear potential. J Acoust Soc Am46: 388–392, 1969.
15.
KuijpersWBontingSL: The cochlear potentials. I. The effect of Ouabain on the cochlear potentials of the guinea pigs. Pfluegers Arch320: 348–358, 1970.
16.
KuijpersWBontingSL: The cochlear potentials. II. The nature of the cochlear endolymphatic resting potential. Pfluegers Arch320: 359–372, 1970.
