Dendritic cells containing melanin pigment have been demonstrated with silver impregnation and bleaching techniques in the nasal cavities of both Caucasians and Negroes. They were found in the respiratory epithelium, nasal glands and commonly in the superficial and deep stroma of the septum and middle and inferior turbinates, particularly in adult Negroes. The presence of melanocytes explains the histogenesis of melanomas of the nasal cavity as primary neoplasms at this site.
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References
1.
GoldmanJLLawsonWZakFG: The presence of melanocytes in the human larynx. Laryngoscope82: 824–835, 1972
2.
PackGTGerberDMScharnagelIM: End results in the treatment of malignant melanoma: A report of 1190 cases. Ann Surg136: 905–911, 1952
3.
MooreESMartinH: Melanoma of the upper respiratory tract and oral cavity. Cancer8: 1167–1171, 1955
4.
AllenACSpitzS: Malignant melanoma. Clinicopathological analysis of the criteria for diagnosis and prognosis. Cancer6: 145, 1953
5.
PantazopoulosPE: Primary malignant melanoma of the nasal fossa. Ann Otol Rhinol Laryngol74: 604–610, 1965
6.
RavidJMEstevesJA: Malignant melanoma of the nose and paranasal sinuses and juvenile melanoma of the nose. Arch Otolaryngol72: 431–444, 1960
7.
MesaraBWBurtonWD: Primary malignant melanoma of the upper respiratory tract. Cancer: 21: 217–225, 1968
8.
HarrisonDF: Malignant melanomata of the nasal cavity. Proc R Soc Med61: 13–18, 1968
MiltonGWLane-BrownMM: Malignant melanoma of the nose and mouth. B J Surg52: 484–493, 1965
11.
LewisMGMartinJAM: Malignant melanoma of the nasal cavity in Ugandan Africans. Relationship of ectopic pigmentation. Cancer20: 1699–1705, 1967
12.
LaidlawGFCahnLR: Melanoblasts in gum. J Dent Res12: 534–537, 1932
13.
WalkerEASnowJB: Management of melanoma of nose and paranasal sinuses. Arch Otolaryngol89: 652–660, 1969
14.
CatlinD: Mucosal melanomas of the head and neck. Am J Roentgenol Radium Ther Nucl Med99: 809–816, 1967
15.
CroneRP: Malignant amelanotic melanomas of the nasal septum and maxillary sinus. Laryngoscope76: 1826–1833, 1966
16.
MoreyG: A case of nasal melanoma. J Laryngol Otol66: 191–192, 1952
17.
von BrunnA: Beiträge zur mikroskopischen Anatomie der menschlichen Nasenhöhle. Arch Mikr Anat39: 632–652, 1892
18.
OppikoferE: Beiträge zur normalen and pathologischen Anatomie der Nase und ihrer Nebenhöhlen. Arch Laryng Rhinol19: 28–84, 1907
19.
SzaboG: Quantitative histological investigations on the melanocyte system of the human epidermis, in GordonM. (ed): Pigment Cell Biology.New York, Academic Press, 1959, p 102