A case presentation of a patient receiving 8 gm of neomycin intramuscularly in preparation for surgery is presented. Acute renal failure and total deafness followed this injection and the temporal bones were removed on the seventeenth day postinjection. Histological findings showed inner and outer hair cell degeneration and a normal spiral ganglion count. There were some changes in the stria vascularis which were noted in the basal turn.
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References
1.
RubenRJDalyJF: Neomycin ototoxicity and nephrotoxicity. A case report following oral administration. Laryngoscope78: 1734–1737, 1968.
2.
GibsonWS: Deafness due to orally administered neomycin. Arch Otolaryng86: 163–165, 1967.
3.
GreenbergLHMomaryH: Audio-toxicity and nephrotoxicity due to orally administered neomycin. JAMA194: 827–828, 1965.
4.
BerkDPChalmersT: Deafness complicating antibiotic therapy of hepatic encephalopathy. Ann Int Med73: 393–396, 1970.
5.
MyersonMKnightHFGambariniAJ: Intrapleural neomycin causing ototoxicity. Ann Thorac Surg9: 483–486, 1970.
6.
GruhlVR: Renal failure, deafness and brain lesions following irrigation of the mediastinum with neomycin. Ann Thorac Surg11: 376–379, 1971.
7.
NilgesTCNorthernJL: Iatrogenic ototoxic hearing loss. Ann Surg.173: 281–289, 1971.
8.
DeBeukelaerMMTravisLBDodgeWF: Deafness and acute tubular necrosis following parenteral administration of neomycin. Amer J Dis Child121: 250–252, 1971.
9.
StuppHF: Untersuchung der Antibiotikaspiegel in den innen Ohrfiüssigkeiten und ihre Bedeutung für die spezifische ototoxizität der Aminoglykosidantibiotika. Acta Oto-laryngSuppl262: 1–85, 1970.
10.
NordNMWatanabeFParkerRH: Comparative acute toxicity of four drugs. A study of neomycin, gentamycin, kanamycin and dihydrostreptomycin. Arch Intern Med119: 493–502, 1967.
11.
BeardNSJrArmentroutSAWeisbergerAS: Inhibition of mammalian protein synthesis by antibiotics. Pharmacol Rev21: 213–245, 1969.
12.
KackerSK: Neomycin-induced spiral organ degeneration in the guinea pig. A study using the surface specimen technique. Laryngoscope80: 391–399, 1970.
13.
KohonenA: Effect of some ototoxic drugs upon the pattern and innervation of cochlear sensory cells in the guinea pig. Acta Oto-laryngSuppl208: 1–70, 1965.
14.
StebbinsWCMillerJMJohnssonLG: Ototoxic hearing loss and cochlear pathology in the monkey. Ann Otol78: 1007–1025, 1969.
15.
LindsayJRProctorLRWorkWP: Histopathologic inner ear changes in deafness due to neomycin in a human. Laryngoscope70: 382–392, 1960.
16.
CroweSJGuildSRPolvogtLM: Observations on the pathology of high tone deafness, Bulletin of the Johns Hopkins Hospital14: 315–381, 1934.
