A study of 13 patients with laryngeal papillomas is presented, with an analysis of epidemiologic factors, electron microscopic study of the lesion, and therapeutic trial of frequent microlaryngoscopic surgery and application of idoxuridine. Five of the nine children in this group were delivered by mothers who had condyloma accuminatum at time of delivery. These five children developed symptoms and required surgery much earlier than the other four. This correlation is shown to be statistically significant. The electron microscopic study of tissue specimens from all our patients failed to find any actual virus particles. The comparison study with skin and genital warts, however, showed ultrastructural details linking the three lesions. Results of the therapeutic program showed an overall improvement in frequency of recurrence, but no complete cures. This improvement is felt to be related to frequent complete surgical excision, and not to application of idoxuridine.
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References
1.
WebbWW: Papilloma of the larynx. Laryngoscope66: 980–984, 1956.
2.
MackenzieM: Essays on Growths in the Larynx with Reports and an Analysis of One Hundred Consecutive Cases Treated by the Author.Philadelphia, Lindsay and Blakiston, 1871.
3.
IshikawaK: Experimentalle Studien uber die transplantation des papilloma. Fukuoka Otol8: 68–76, 1936.
4.
HolingerPHJohnstonKCConnerGH: Studies of papilloma of the larynx. Ann Otol71: 443–447, 1962.
5.
Al-SaleemTPealeARNorrisCM: Multiple papillomatosis of the lower respiratory tract. Cancer22: 1174–1184, 1968.
6.
HolingerPHSchildJAMaurizDG: Laryngeal papilloma, review of etiology and therapy. Laryngoscope78: 1462–1474, 1968.
7.
BroylesEN: Treatment of laryngeal papilloma in children. Southern Med J34: 239–242, 1941.
8.
OnoSSaitoHIgarashiM: The etiology of papilloma of the larynx. Ann Otol66: 1119–1142, 1957.
9.
ShilovtsevaAS: The complex treatment of patients affected with papillomatosis of the larynx and trachea. Vest Otol29: 74–79, 1967.
10.
BjorkHWeberC: Papilloma of the larynx. Acta Otolaryng46: 499–516, 1956.
11.
UhlmanEV: On the etiology of the laryngeal papilloma. Acta Otolaryng5: 317–325, 1923.
12.
ReslerDRSnowJB: Cell-free nitrate transplantation of human laryngeal papilloma to dogs. Laryngoscope77: 397–416, 1967.
13.
MeessenHSchulzH: Elektronenmikroskopischer nachineis des virus in kehlkopfpapillom des menschen. Klin Wschr35: 771–774, 1957.
14.
DmochowskiLGreyCESykesJA: Study of submicroscopic structure and of virus particles in cells of human laryngeal papillomas. Tex Rep Biol Med22: 454–491, 1964.
15.
BoyleWFMcCoyEGFogartyWA: Electron microscopic identification of virus-like particles in laryngeal papilloma. Ann Otol80: 693–398, 1971.
16.
SvobodaDJKirchnerFRProudGO: Electron microscopic study of human laryngeal papillomatosis. Can Res23: 1084–1089, 1963.
17.
AlmeidaJDHowatsonAFWilliamsMG: Electron microscope study of human warts: site of virus production and nature of the inclusion bodies. J Invest Derm38: 337–345, 1962.
18.
ZimmersS: Morphogischer virusnachweis bei spitzen kondvlomen. Abl Gynak86: 1116–1119, 1964.
19.
DunnAEGOglivieMM: Intranuclear virus particles in human genital wart tissue: observations on the ultrastructure of the epidermal layer. J Ultrastruct Res22: 282–295, 1968.
20.
OrielJDAlmeidaJD: Demonstration of virus particles in human genital warts. Brit J Vener Dis46: 37–42, 1970.
21.
Barrera-OraJGSmithKOMelnickJL: Quantitation of papovavirus particles in human warts. J Natl Cancer Inst29: 583–393, 1962.
22.
ButelJS: Studies with human papilloma virus modeled after known papovavirus systems. J Natl Cancer Inst48: 285–299, 1972.
23.
HolingerPHJohnsonKCAnisonGC: Papilloma of the larynx: a review of 109 cases with a preliminary report of aureomycin therapy. Ann Otol59: 547–564, 1950.
