XXXIV The Treatment of Head and Neck Cancer with the Continuous Arterial Infusion of Methotrexate and the Intermittent Intramuscular Administration of Citrovorum Factor

Burchenal J. H. Murphy M. L. Ellison R. R. Sykes M. P. Tan T. C. Leone L. A. Karnofsky D. A. Craver L. F. Dargeon H. W. Rhoads C. P. : Clinical Evaluation of New Antimetabolite, 6-Mercaptopurine, in Treatment of Leukemia and Allied Diseases. Blood 8:965–999, 1953.

Curreri A. R. Ansfield F. J. McIver F. A. Waisman H. A. Heidelberger C. : Clinical Studies with 5-Fluorouracil. Cancer Res. 18:478–484, figs. 1–9, 1958.

Karnofsky D. A. Burchenal J. H. Armistead G. C. Jr. Southam C. M. Bernstein J. L. Craver L. F. Rhoads C. P. : Triethylene Melamine in Treatment of Neoplastic Disease; Compound with Nitrogen-Mustard-Like Activity Suitable for Oral and Intravenous Use. A.M.A. Arch. Int. Med. 87:477–516, 1951.

Magill G. B. Myers W. P. L. Reilly H. C. Putnam R. C. Magill J. W. Sykes M. P. Escher G. C. Karnofsky D. A. Burchenal J. H. : Pharmacological and Initial Therapeutic Observations on 6-Diazo-5-oxo-L-norleucine (DON) in Human Neoplastic Disease. Cancer 10:1138–1150, 1957.

Taylor S. G. Hass G. M. III Crumrine J. L. Slaughter D. P. : Toxic Reactions of 4-Amino-pteroylglutamic Acid (Aminopterin) in Patients with Far-Advanced Neoplastic Disease. Cancer 3:493–503, 1950.

Sullivan R. D. Miller E. Murphy V. B. Mechanic R. : The Value of 5-Fluorouracil in Human Cancer. Proc. of the Amer. Assn. for Cancer Research 3:1:68 (Mar.) 1959. (Abstr.).

Karnofsky D. A. : Nitrogen Mustards in Treatment of Neoplastic Disease. Advances Int. Med. 4:1–75, 1950.

Karnofsky D. A. : Summary of Results Obtained with Nitrogen Mustard in Treatment of Neoplastic Disease. Ann. New York Acad. Sc. 68:899–914, 1958.

Sullivan R. D. : Myleran Therapy in Bronchogenic Carcinoma. Ann. New York Acad. Sc. 68:1038–1045, 1958.

Miller E. : Clinical Trials of Nonane in Malignant Disease. Ann. New York Acad. Sc. 68:1205–1210, 1958.

Rhoads C. P. : Nitrogen Mustards in Treatment of Neoplastic Disease; Official Statement. J.A.M.A. 131:656–658, 1946.

Ellison R. R. Karnofsky D. A. Sternberg S. S. Murphy M. L. Burchenal J. H. : Clinical Trials of O-diazoactyl-L-serine (Azaserine) in Neoplastic Disease. Cancer 7:801–814, 1954.

Tan C. T. C. Dargeon H. W. Burchenal J. H. : Effects of Actinomycin D on Cancer in Childhood. Pediatrics 24:544, 1959.

Hackenthal C. A. Golbey R. B. Tan C. T. C. Karnofsky D. A. Burchenal J. H. : Clinical Observations on the Effects of Streptonigrin in Patients with Neoplastic Disease. Antib. and Chemotherapy (in press).

Colsky J. Escher G. C. Evans A. Mitus A. Li M. C. Roath S. Sullivan R. D. Sykes M. P. Tan C. T. C. : Preliminary Clinical Pharmacology of Mitomycin C. Proc. Amer. Assoc. Cancer Research 3:13, 1959.

Submitted by the Cooperating Investigators: Mitomycin C - A Preliminary Report of Studies of Human Pharmacology and Initial Therapeutic Trial. Cancer Chemotherapy Reports 2:3–7, 1959.

Klopp C. T. Alford T. C. Bateman J. Berry G. N. Winship T. : Fractionated Intra-Arterial Cancer; Chemotherapy with Methyl Bis Amine Hydrochloride; Preliminary Report. Ann. Surg. 132:811–832, 1950.

Krakoff I. H. Sullivan R. D. : Intra-Arterial Nitrogen Mustard in Treatment of Pelvic Cancer. Ann. Int. Med. 48:839–850, 1958.

Sullivan R. D. Jones R. Jr. Schnabel T. G. Jr. Shorey J. M. : Treatment of Human Cancer with Intra-Arterial Nitrogen Mustard (Methylbis(2-chlorethyl) amine hydrochloride) Utilizing Simplified Catheter Technique. Cancer 6:121–134, 1953.

Sullivan R. D. Mescon H. Jones R. Jr. : Effect of Intra-Arterial Nitrogen-Mustard (Methylbis(2-chlorethyl)amine hydrochloride) Therapy on Human Skin. Cancer 6:288–293, 1953.

Karnofsky D. A. Burchenal J. H. Ormsbee R. A. Corman I. Rhoads C. P. : Experimental Observations on Use of Nitrogen Mustards in Treatment of Neoplastic Disease; in Moulton F. R. , Ed.: Approaches to Tumor Chemotherapy. Washington, D. C., Amer. Assoc. for the Advancement of Sci., pp. 293–305, 1947.

Hartman S. C. Levenberg B. Buchanan J. M. : Involvement of ATP, 5-Phosphoribosylpyrophosamide and L-Azaserine in Enzymatic Formation of Glycinamide Ribotide Intermediates in Inosinic Acid Biosynthesis. J. Am. Chem. Soc. 77:501–503, 1955.

Heidelberger C. Chaudhuri N. K. Danneberg P. Mooren D. Griesbach L. Duschinsky R. Schnitzer R. J. Pleven E. Scheiner J. : Fluorinated Pyrimidines, New Class of Tumour-Inhibitory Compounds. Nature, London 179:663–666, 1957.

Skipper H. E. Bennett L. L. Jr. Schabel F. M. Jr. : Mechanism of Action of Azaserine. Fed. Proc. 13:298–299, 1954.

Sullivan R. D. : (Personal Communication).

Farber S. Diamond L. K. Mercer R. D. Sylvester R. F. Jr. Wolff J. A. : Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminoptcroyl-Glutamic Acid (Aminopterin). New England J. Med. 238:787–793, 1948.

Miner R. W. , Ed.: 6-Mercaptopurine. Ann. New York Acad. Sc. 60:183–508, 1954.

Burchenal J. H. Kingslye-Pillers E. M. : Studies on Amethopterin, Citrovorum Factor, and Crude X-methyl Folic Acid in Leukemia (Abstr.). J. Clin. Invest. 30:631–632, 1951.

Murphy M. L. Ellison R. R. Karnofsky D. A. Burchenal J. H. : Clinical Effects of Dicloro and Monochloro-phenyl Analogues of Diamino Pyrimidine; Antagonists of Folic Acid. J. Clin. Invest. 33:1388–1396, 1954.

Sullivan R. D. Miller E. Sykes M. P. : Antimetabolite-Metabolite Combination Cancer Chemotherapy. Effects of Intra-Arterial Methotrexate-Intramuscular Citrovorum Factor Therapy in Human Cancer. Cancer 12:6:1248–1262, 1959.

Sullivan R. D. Miller E. Wood A. M. Clifford P. Duff J. K. Trussell R. Burchenal J. H. : Continuous Infusion Cancer Chemotherapy in Humans— Effects of Therapy with Intra-Arterial Methotrexate Plus Intermittent Intramuscular Citrovorum Factor. Cancer Chemotherapy Reports 10:39–42, 1960.

Sullivan R. D. : Continuous Arterial Infusion of Methotrexate with Intermittent, Intramuscular Citrovorum Factor Therapy in Head and Neck. Transactions of the Pacific Coast Oto-Ophthalmological Society (in press).

Sullivan R. D. Wood A. M. Clifford P. Duff J. K. Trussell R. Nary D. J. Burchenal J. H. : Continuous Intra-Arterial Methotrexate with Simultaneous, Intermittent Intramuscular Citrovorum Factor Therapy in Carcinoma of the Cervix. Cancer Chemotherapy Reports 8:1–6, 1960.

Sullivan R. D. Miller E. Duff J. K. : Effects of Continuous Intra-Arterial Methotrexate with Intermittent Intramuscular Citrovorum Factor Therapy in Human Cancer. Proc. of Amer. Assoc. for Cancer Research 3:3:271 (Abstr. No. 273) 1961.

Creech O. Ryan R. F. Winblad J. N. : Regional Perfusion Utilizing an Extra-Corporeal Circuit. Ann. Surg. 148:616, 1958.

Duff J. K. Sullivan R. D. Miller E. Ulm A. H. Clarkson B. D. Clifford P. : Antimetabolite-Metabolite Cancer Chemotherapy Using Continuous Intra-Arterial Methotrexate with Intermittent Intramuscular Citrovorum Factor. Method of Therapy. (In press - will appear in July-August issue of Cancer, 1961.).

Liguori V. R. Giglio J. J. Miller E. Sullivan R. D. : The Effects of Different Dosage Schedules of Methotrexate on Sera and Tissue Levels and Urinary Excretion Patterns. (In press).

Sullivan R. D. Young C. W. Miller C. Glatstein N. Clarkson B. Burchenal J. H. : The Clinical Effects of the Continuous Administration of Fluorinated Pyrimidines (5-Fluorouracil and 5-Fluoro-2′-deoxyuridine). Cancer Chemotherapy Reports 8:77–83, 1960.

Miller E. Sullivan R. Young C. Burchenal J. H. : Clinical Effects of the Continuous Infusion of Antimetabolites—Prevention of Toxicity of 5-Fluoro-2'-deoxyuridine by Thymidine. Proc. of Amer. Assoc. for Cancer Research 3:3:251 (Abstr. No. 192) 1961.