PalaciosSDPakKKayaliAG. Participation of Ras and extracellular regulated kinase in the hyperplastic response of middle-ear mucosa during bacterial otitis media. J Infect Dis2002;186:1761–9.
2.
YetiserSSatarBAydinN. Expression of epidermal growth factor, tumor necrosis factor–alpha, and interleukin-1 alpha in chronic otitis media with or without cholesteatoma. Otol Neurotol2002;23:647–52.
3.
JungHHKimMWLeeJH. Expression of vascular endothelial growth factor in otitis media. Acta Otolaryngol (Stockh)1999;119:801–8.
4.
MelhusARyanAF. Expression of molecular markers for bone formation increases during experimental acute otitis media. Microb Pathog2001;30:111–20.
5.
PalaciosSDOehlHJRivkinAZAletseeCPakKRyanAF. Growth factors influence growth and differentiation of the middle ear mucosa. Laryngoscope2001;111:874–80.
6.
PalaciosSDPakKRivkinAZBennettTRyanAF. Growth factors and their receptors in the middle ear mucosa during otitis media. Laryngoscope2002;112:420–3.
7.
HuttonDAFoggFJKubbaHBirchallJPPearsonJP. Heterogeneity in the protein cores of mucins isolated from human middle ear effusions: Evidence for expression of different mucin gene products. Glycoconj J1998;15:283–91.
8.
LinJTsuprunVKawanoH. Characterization of mucins in human middle ear and eustachian tube. Am J Physiol Lung Cell Mol Physiol2001;280:L1157–L1167.
9.
JonoHShutoTXuH. Transforming growth factor-beta-Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription. J Biol Chem2002;277:45547–57.
10.
WangBLimDJHanJKimYSBasbaumCBLiJD. Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway. J Biol Chem2002;277:949–57.
11.
TakeuchiKYagawaMIshinagaHKishiokaCHaradaTMajimaY. Mucin gene expression in the effusions of otitis media with effusion. Int J Pediatr Otorhinolaryngol2003;67:53–8.
12.
LinJTsuboiYPanWGiebinkGSAdamsGLKimY. Analysis by cDNA microarrays of altered gene expression in middle ears of rats following pneumococcal infection. Int J Pediatr Otorhinolaryngol2002;65:203–11.
13.
JonoHXuHKaiH. Transforming growth factor-beta–Smad signaling pathway negatively regulates nontypeable Haemophilus influenzae-induced MUC5AC mucin transcription via mitogen-activated protein kinase (MAPK) phosphatase-1-dependent inhibition of p38 MAPK. J Biol Chem2003;278:27811–9.
14.
KimYTJungHHKoTOKimSJ. Up-regulation of MUC5AC mRNA expression in endotoxin-induced otitis media. Acta Otolaryngol (Stockh)2001;121:364–70.
15.
LinJHarutaAKawanoH. Induction of mucin gene expression in middle ear of rats by tumor necrosis factor–alpha: Potential cause for mucoid otitis media. J Infect Dis2000;182:882–7.
16.
SmirnovaMGBirchallJPPearsonJP. TNF-alpha in the regulation of MUC5AC secretion: Some aspects of cytokine-induced mucin hypersecretion on the in vitro model. Cytokine2000;12:1732–6.
17.
SongKSLeeWJChungKC. Interleukin-1 beta and tumor necrosis factor–alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J Biol Chem2003;278:23243–50.
18.
SmirnovaMGBirchallJPPearsonJP. In vitro study of IL-8 and goblet cells: Possible role of IL-8 in the aetiology of otitis media with effusion. Acta Otolaryngol (Stockh)2002;122:146–52.
19.
MoonSKYooJHKimHNLimDJChungMH. Effects of retinoic acid, triiodothyronine and hydrocortisone on mucin and lysozyme expression in cultured human middle ear epithelial cells. Acta Otolaryngol (Stockh)2000;120:944–9.
20.
FergieNGuoLSitholeJPearsonJPBirchallJP. Influence of prednisolone on the secretion of mucin from the HT29-MTX cell line. Clin Otolaryngol2003;28:39–42.
21.
SoininenAKarpalaMWahlmanSLLehtonenHKayhtyH. Specificities and opsonophagocytic activities of antibodies to pneumococcal capsular polysaccharides in sera of unimmunized young children. Clin Diagn Lab Immunol2002;9:1032–8.
22.
MoonSKLeeHYLiJD. Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1 alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells. Biochim Biophys Acta2002;1590:41–51.
23.
LimDJChunYMLeeHY. Cell biology of tubotympanum in relation to pathogenesis of otitis media — A review. Vaccine2000;19(suppl 1): S17–S25.
24.
StenforsLEByeHMRaisanenS. Causes for massive bacterial colonization on mucosal membranes during infectious mononucleosis: Implications for acute otitis media. Int J Pediatr Otorhinolaryngol2002;65:233–40.
25.
ChungMHChoiJYLeeWSKimHNYoonJH. Compositional difference in middle ear effusion: Mucous versus serous. Laryngoscope2002;112:152–5.
26.
NellMJAlbers-Op't HofBMKoertenHKGroteJJ. Inhibition of endotoxin effects on cultured human middle ear epithelium by bactericidal permeability-increasing protein. Am J Otol2000;21:625–30.
27.
Narkio-MakelaMMeriS. Cytolytic complement activity in otitis media with effusion. Clin Exp Immunol2001;124:369–76.
28.
Narkio-MakelaMHellwageJTahkokallioOMeriS. Complement-regulator factor H and related proteins in otitis media with effusion. Clin Immunol2001;100:118–26.
29.
Narkio-MakelaMTeppoAMMeriS. Complement C3 cleavage and cytokines interleukin-1 beta and tumor necrosis factor–alpha in otitis media with effusion. Laryngoscope2000;110:1745–9.
30.
Narkio-MakelaMJeroJMeriS. Complement activation and expression of membrane regulators in the middle ear mucosa in otitis media with effusion. Clin Exp Immunol1999;116:401–9.
31.
WizemannTMHeinrichsJHAdamouJE. Use of a whole genome approach to identify vaccine molecules affording protection against Streptococcus pneumoniae infection. Infect Immun2001;69:1593–8.
32.
DopazoJMendozaAHerreroJ. Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate. Microb Drug Resist2001;7:99–125.
33.
TettelinHNelsonKEPaulsenIT. Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science2001;293:498–506.
34.
HoskinsJAlbornWEJr.ArnoldJ. Genome of the bacterium Streptococcus pneumoniae strain R6. J Bacteriol2001;183:5709–17.
35.
LauGWHaatajaSLonettoM. A functional genomic analysis of type 3 Streptococcus pneumoniae virulence. Mol Microbiol2001;40:555–71.
36.
MarraAAsundiJBartilsonM. Differential fluorescence induction analysis of Streptococcus pneumoniae identifies genes involved in pathogenesis. Infect Immun2002;70:1422–33.
37.
RigdenDJGalperinMYJedrzejasMJ. Analysis of structure and function of putative surface-exposed proteins encoded in the Streptococcus pneumoniae genome: A bioinformatics-based approach to vaccine and drug design. Crit Rev Biochem Mol Biol2003;38:143–68.
38.
PatonJCGiammarinaroP. Genome-based analysis of pneumococcal virulence factors: The quest for novel vaccine antigens and drug targets. Trends Microbiol2001;9:515–8.
39.
van SchilfgaardeMvan UlsenPvan Der SteegW. Cloning of genes of nontypeable Haemophilus influenzae involved in penetration between human lung epithelial cells. Infect Immun2000;68:4616–23.
40.
van UlsenPvan SchilfgaardeMDankertJJansenHvan AlphenL. Genes of non-typeable Haemophilus influenzae expressed during interaction with human epithelial cell lines. Mol Microbiol2002;45:485–500.
41.
MasonKMMunsonRSJr.BakaletzLO. Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media. Infect Immun2003;71:3454–62.
42.
HouYGuXX. Development of peptide mimotopes of lipooligosaccharide from nontypeable Haemophilus influenzae as vaccine candidates. J Immunol2003;170:4373–9.
43.
ThorenKGustafssonEClevnertALarssonTBergstromJNilssonCL. Proteomic study of non-typable Haemophilus influenzae. J Chromatogr B Analyt Technol Biomed Life Sci2002;782:219–26.
44.
HaysJPvan der ScheeCLoogmanA. Total genome polymorphism and low frequency of intra-genomic variation in the uspA1 and uspA2 genes of Moraxella catarrhalis in otitis prone and non-prone children up to 2 years of age. Consequences for vaccine design?. Vaccine2003;21:1118–24.
