A prospective study was performed to evaluate the rhinomanometric values and the changes in the olfactory threshold that occur in women throughout the menstrual cycle. The subjects were 60 healthy volunteer premenopausal women 18 to 40 years of age. We performed rhinomanometric and olfactometric measurements during the follicular, periovular, and luteal phases of the menstrual cycle. Rhinomanometry showed a higher (not statistically significant) airflow during the periovular phase than during the follicular and luteal phases. Olfactometry showed a higher sensitivity during the follicular phase (p < .05) and the periovular phase (p < .001) than during the luteal phase. We conclude that airflow and transnasal pressure during spontaneous respiration, as well as the olfactory threshold to odors, seem to depend on the variations of the ovarian steroids that occur during the menstrual cycle.
FingerTESilverWL. Overview and introduction. In: FingerTESilverWL, eds. Neurobiology of taste and smell. Malabar, Fla: Krieger Publishing Co, 1991: 3–10.
2.
MurphyC. Olfactory psychophysics. In: FingerTESilverWL, eds. Neurobiology of taste and smell. Malabar, Fla: Krieger Publishing Co, 1991: 251–68.
3.
VierlingJSRockJ. Variations in olfactory sensitivity to exaltolide during the menstrual cycle. J Appl Physiol1967; 22: 311–5.
4.
EvansWJCuiLStarrA. Olfactory event-related Potentials in normal human subjects: Effects of age and gender. Electroencephalogr Clin Neurophysiol1995; 95: 293–301.
5.
LehrnerJPGluckJLaskaM. Odor identification, consistency of label use, olfactory threshold and their relationship to odor memory over the human lifespan. Chem Senses1999; 24: 337–46.
6.
Le MagnenJ. Les phenomenes olfacto-sexuels chez l'homme. Arch Sci Physiol1952; 6: 125–60.
7.
DotyRLSnyderPJHugginsGRLowryLD. Endocrine, cardiovascular, and psychological correlates of olfactory sensitivity changes during the human menstrual cycle. J Comp Physiol Psychol1981; 95: 45–60.
8.
MairRGBouffardJAEngenTMortonTH. Olfactory sensitivity during the menstrual cycle. Sens Processes1978; 2: 90–8.
9.
DotyRLFordMPretiGHugginsGR. Changes in the intensity and pleasantness of human vaginal odors during the menstrual cycle. Science1975; 190: 1316–8.
10.
PoranNS. Cyclic attractivity of human female odors. In: ApfelbachRMuller-SchwarzeDReutterKWeilerE, eds. Chemical Signals in vertebrates VII. Oxford, England: Elsevier Science Ltd, 1994: 561–9.
11.
UdryJRMorrisNM. Distribution of coitus in the menstrual cycle. Nature1968; 220: 593–6.
12.
KleinLL. Observations on copulation and seasonal reproduction of two species of spider monkeys, Ateles belzebuth and A geoffroyi. Folia Primatol (Basel)1971; 15: 232–48.
13.
ShortRV. Human reproduction in an evolutionary context. Ann N Y Acad Sci1994; 709: 416–25.
14.
PauseBSojkaBKrauellKFerstlR. Characteristics of olfactory evoked potentials in women change depending on the phase of menstrual cycle. In: ApfelbachRMuller-SchwarzeDReutterKWeilerE, eds. Chemical Signals in vertebrates VII. Oxford, England: Elsevier Science Ltd, 1994: 549–54.
15.
McClintockM. Pheromonal regulation of the ovarian cycle. In: VandenberghJG, ed. Pheromones and mammalian reproduction. New York, NY: Academic Press, 1983: 245–51.
16.
RussellMJ. Human olfactory communication. Nature1976; 260: 520–2.
17.
CutlerWBPretiGKriegerAHugginsGRGarciaCRLawleyHJ. Human axillary secretions influence women's menstrual cycles: The role of donor extract from men. Horm Behav1986; 20: 463–73.
18.
PretiGCutlerWBGarciaCRHugginsGRLawleyHJ. Human axillary secretions influence women's menstrual cycles: The role of donor extract of females. Horm Behav1986; 20: 474–82.
19.
MaiwormRE. Influence of androstenol, androsterone, menstrual cycle and oral contraceptives on the attractivity ratings of female probands. Ninth European Congress of Gynecologists and Obstetricians, Amsterdam, the Netherlands, 1990: 2–7.
20.
SokolovVEVoznesenskaiaVVZinkevichEP. Olfactory cues and ovarian cycles. In: DotyRLMuller-SchwarzeD, eds. Chemical Signals in vertebrates 6. New York, NY: Plenum Press, 1992: 267–70.
21.
AmooreJEOllmanBG. Practical test kits for quantitatively evaluating the sense of smell. Rhinology1983; 21: 49–54.
22.
CainWSGentJCatalanottoAGoodspeedRB. Clinical evaluation of olfaction. Am J Otolaryngol1983; 4: 252–6.
23.
DotyRLShamanPDannM. Development of the University of Pennsylvania Smell Identification Test: A standardized microencapsulated test of olfactory function. Physiol Behav1984; 32: 489–502.
24.
FortunatoVBindoniMAuritiGD' AngeloE. Research on various structural and functional aspects of olfactive perception [in French]. Acta Otorhinolaryngol Belg1972; 26: 506–10.
25.
LawlessHZwillenbergD. Clinical testing of taste and olfaction. Trans Pa Acad Ophthalmol Otolaryngol1983; 36: 190–6.
26.
MurphyCCainWS. Taste and olfaction: Independence vs interaction. Physiol Behav1980; 24: 601–5.
27.
KeverneEBMurphyCLSilverWLWysockiCJMeredithM. Non-olfactory chemoreceptors of the nose: Recent advances in understanding the vomeronasal and trigeminal system. Chem Senses1986; 11: 119–33.
