A 50-year-old man presented spontaneous internal carotid artery dissection with ischemic stroke. He had a history of deep venous thrombosis, and an activated protein C resistance due to factor V Leiden mutation was documented. He showed no other vascular risk factor. This unusual case puts the question whether this coagulation defect may be related to the stroke occurrence.
Get full access to this article
View all access options for this article.
References
1.
Bertina RM, Koeleman Bpc, Koster T., et al: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature369:64-67, 1994.
2.
Koster T., Rosendaal FR, de Ronde H., et al: Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet342:1503-1506, 1993.
3.
Ridker PM, Hennekens CH, Lindpaintner K., et al: Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke and venous thrombosis in apparently healthy men. N Engl J Med332:912-917, 1995.
4.
Kontula K., Ylokorkala A., Miettinen H., et al: Arg506G1n factor V mutation (factor V Leiden) in patients with ischaemic cerebrovascular disease and survivors of myocardial infarction. Thromb Haemost73:558-560, 1995.
5.
Simioni P., de Ronde H., Prandoni P., et al: Ischemic stroke in young patients with activated protein C resistance : A report of three cases belonging to three different kindreds. Stroke26:885-890, 1995.
6.
Lalouschek W. , Suess E., Aull S., et al: Clinical and laboratory data in heterozygous factor V Leiden mutation positive versus negative patients with TIA and minor stroke. Stroke26:1963-1964, 1995 (letter).
7.
Catto A., Carter A., Grant PJ: Factor V Leiden mutation and complete stroke . Stroke27:573, 1996 (letter).
8.
Press RD, Liu XY, Beamer N., et al: Ischemic stroke in the elderly. Role of the common factor mutation causing resistance to activated protein C. Stroke27:44-48, 1996.
9.
Albucher JF, Guiraud-Chaumeil B., Chollet F., et al: Frequency of resistance to activated protein C due to factor V mutation in young patients with ischemic stroke. Stroke27:766-767, 1996 (letter).
10.
Yamamoto H. , Bogousslavsky J.: Resistance to activated protein C: Another risk of cerebral infarction. Cerebrovasc Dis6:18, 1996 (abstract).
11.
Fisher M., Fernandez JA, Ameriso SF, et al: Activated protein C resistance in ischemic stroke not due to factor V arginine-glutamine mutation. Stroke27:1163-1166, 1996.
12.
Cadroy Y., Sié P., Boneu B.: Frequency of a defective response to activated protein C in patients with a history of venous thrombosis. Blood83:2208-2209, 1994.
13.
Leys D., Lucas C., Gobert M., et al: Cervical artery dissections. Eur Neurol37:3-12, 1997.
