Cancer chemotherapy is associated with a wide range of vascular toxicities, which may be related to endothelial cell damage by these agents. The authors describe a patient with Hodgkin's disease who developed an atypical aortic dissection while receiving MOPP/ABV chemotherapy (nitrogen mustard, vincristine, procarbazine, prednisone, doxorubicin, bleomycin, and vinblastine). They would place aortic dissection on the list of potential vascular complications associated with antineoplastic agents.
Adamson Iyr, Bowden DH: The pathogenesis of bleomycin-induced pulmonary fibrosis in miceAm J Pathol77:185-190, 1974.
5.
Nicholson GL , Custead SE: Effects of chemotherapeutic drugs on platelet and metastatic tumor cell-endothelial cell interactions as a model for assessing vascular endothelial integrityCancer Res45:331-334, 1985.
