Aortoiliac occlusion due to atherosclerosis is known to occur in elderly people. Two unique cases are documented here in which aortoiliac occlusion was observed in young men. These patients had no identifiable risk factors for developing atherosclerotic throm bosis except for the lupus anticoagulant, an immunoglobulin associated with throm boembolic episodes. Although previously the lupus anticoagulant has been reported to cause thrombosis only in relatively small-sized arteries or veins, it may also be associated with aortoiliac atheromatous occlusion in young men.
Get full access to this article
View all access options for this article.
References
1.
Halpert B., Erickson EE, De Bakey ME, et al: Occlusive disease of the abdominal aorta. Structural alterationsArch Pathol65:158-165, 1958.
2.
Friedman SA, Holling HE, Roberts B.: Etiologic factors in aortoiliac and femoropopliteal vascular disease . The Leriche syndrome. N Engl J Med271 : 1382-1385, 1964.
3.
De Bakey ME, Crawford ES, Cooley DA, et al: Surgical considerations of occlusive disease of the abdominal aorta and iliac and femoral arteries. Analysis of 803 cases. Ann Surg148:306-324, 1958.
4.
Perdue GD, Smith RB III: Chronic aortoiliac occlusion. In: The Aorta, ed. by Lindsay J Jr, Hurst JW.New York: Grune & Stratton, 1979, pp 189-223.
5.
Conley CL, Hartman RC: A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus. J Clin Invest31:621-622, 1952.
6.
Lechner K., Pabinger-Fasching I.: Lupus anticoagulants and thrombosis. A study of 25 cases and review of the literature. Haemostasis15:254-262, 1985.
7.
Disler L., Hide G.: An unusual case of occlusive thromboaortopathy. (Takayasu's disease)—a case reportAngiology39:401-404, 1988.
8.
Abu-Dalu J., Giler S., Urca I.: Thromboangitis obliterans of the iliac artery. Report of two cases. Angiology24:359-364, 1973.
9.
Gavrilescu S. , Streian C., Gavrilescu M.: An unusual case of reno-vascular hypertension with multiple arterial stenosis. Angiology27:122-125, 1976.
10.
Mueh JR, Herbst KD, Rapaport SI: Thrombosis in patients with the lupus anticoagulant. Ann Intern Med92:156-159, 1980.
11.
Elias M., Eldor A.: Thromboembolism in patients with the 'lupus'-type circulating anticoagulant . Arch Intern Med144:510-515, 1984.
12.
Boey ML, Colaco CB, Gharavi AE, et al: Thrombosis in systemic lupus erythematosus: Striking association with the presence of circulating lupus anticoagulant. Br Med J287:1021-1023, 1983.
13.
Gastineau DA , Kazmier FJ, Nichols WL, et al: Lupus anticoagulant: An analysis of the clinical and laboratory features of 219 cases. Am J Hematol19 :265-275, 1985.
14.
Glueck HI, Kant KS, Weiss MA, et al: Thrombosis in systemic lupus erythematosus. Relation to the presence of circulating anticoagulants. Arch Intern Med145:1389-1395, 1985.
15.
Freyssinet JM, Cazenave JP: Lupus-like anticoagulants, modulation of the protein C pathway and thrombosis. Thromb Haemostas58:679-681, 1987.
