Three cases of patients with cardiac myxoma who had attacks of acute myocardial infarc tion are presented. Cineangiographic study showed normal coronary arteries. Immunohistochemical and serologic examination revealed that both interleukin-6 and interleukin-8 were secreted in cardiac myxoma. The authors discuss the relation between these cytokines and myocardial infarction with normal coronary arteries.
Get full access to this article
View all access options for this article.
References
1.
Wold LE, Lie JT: Cardiac myxomas. Am J Pathol101:219-233, 1980.
de Morais CF , Falzoni R., Alves Vaf: Myocardial infarct due to a unique atrial myxoma with epithelial-like cells and systemic metastases . Arch Pathol Lab Med112:185-190, 1988.
4.
Block WJ, Parker RL, Edwards TE: "Myxoma" of the left atrium clinically stimulating mitral stenosis. Report of case and pathologic studies. Professional Staff Meeting, Mayo Clinic27:361-371, 1952.
5.
Kanda T., Umeyama S., Sasaki A., et al: Interleukin-6 and cardiac myxoma. Am J Cardiol74:965-967, 1994.
6.
Sakamoto H., Sakamaki T., Wada A., et al: Dexamethasone inhibits production of interleukin-6 by cultured cardiac myxoma cells. Am Heart J127:704-705, 1994.
7.
McAllista HA , Fenoglio JJ: Tumors of the cardiovascular system. In Atlas of Tumor Pathology . Fasc. 15, 2nd Series. Washington, DC: Armed Forces Institute of Pathology, 1978, p 134.
8.
Hoad Mna, Foulds JS: Fortuitous discovery of a left atrial myxoma following acute myocardial infarction . J R Army Med Corps133:13-15, 1987.
9.
Silvermann J. , Olwin J., Graettinger J.: Cardiac myxomas with systemic embolization. Review of the literature and report of a case. Circulation26:99-103, 1962.
10.
Onitsuka T., Koga Y., Kuwabara M., et al: Left atrial myxoma in a 16-year-old girl following acute myocardial infarction—a case report and a review of 17 cases in the world. Nippon Kyobu Geka Gakkai Zasshi39:1178-1183, 1991 .
11.
Oldenburg HS , Rogy MA, Lazarus DD, et al: Cachexia and the acute phase protein in response to inflammation are regulated by interleukin-6. Eur J Immunol23:1889-1894, 1993.
12.
Andus T., Geiger T., Hirano T., et al: Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-β2) regulates β-fibrinogen and albumin mRNA levels in Fao-9 cells. FEBS Letter221:18-22, 1987.
13.
Yarnell Jwg , Baker IA, Sweetman PM, et al: Fibrinogen, viscosity and white blood cell count are major risk factors for ischemic heart disease. Circulation83:836-844, 1991.
14.
Wilhelmsen L., Svardsudd K., Korsan-Bengtsen K., et al: Fibrinogen as a risk factor for stroke and myocardial infarction. N Engl J Med311:501-505, 1984.
15.
Liuzzo G., Biasuggi LM, Gallimore JR, et al: The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N Engl J Med331:417-424, 1994.
16.
Ruffel B., Car BD, Weber M., et al: Long-term interleukin-6 administration stimulates sustained thrombopoiesis and acute-phase protein synthesis in small primates—the marmoset. Blood83:2093-2102, 1994 .
17.
Wang JM, Tarabole HG, Matsushima K., et al: Induction of hepatotactic migration of melanoma cells by neutrophil activity protein/IL-8. Biochem Biophys Res Commun169:165-170, 1990.
18.
Schadendorf D., Moller A., Algermissen B., et al: IL-8 produced by melanoma cells in vitro is an essential autocrine growth factor. J Immunol151:2667-2675, 1993.
19.
Singh RK, Gertman M., Radinsky R., et al: Expression of interleukin 8 correlates with metastatic potential of human melanoma cells in nude mice. Cancer Res54:3242-3247, 1994.
