A seventy-four-year-old woman with arteriosclerosis obliterans, diabetes mellitus, and hypertension was admitted for the treatment of intermittent claudication and coldness and pain in the right lower extremity. After the administration of a vasopressin V1 antag onist, OPC21268, the symptoms were markedly improved. Furthermore, blood flow in the dorsalis pedis artery and the cutaneous temperature in the right foot increased in response to acute and chronic administration of OPC21268. OPC21268 may be a new useful therapeutic tool for the treatment of arteriosclerosis obliterans.
Get full access to this article
View all access options for this article.
References
1.
Liard JF, Deriaz O., Schelling P., et al: Cardiac output distribution during vasopressin infusion or dehydration in conscious dogs. Am J Physiol243:H663-669, 1982.
2.
Saxena PR, Schoemaker RG: Organ blood flow protection in hypertension and congestive heart failure. Am J Med94(suppl 4A):4S-12S, 1993.
3.
Wanless RB, Anand IS, Gurden J., et al: Regional blood flow and hemodynamics in the rabbit with Adriamycin cardiomyopathy: Effect of isosorbide dinitrate, dobutamine and captopril. J Pharmacol Exp Ther243:1101-1106, 1987 .
4.
Zelis R., Sinoway LI, Musch TI, et al: Regional blood flow in congestive heart failure: Concept of compensatory mechanism with short and long time constants. Am J Cardiol62 (suppl E):2-8, 1988.
5.
Charocopos F. , Hatzinikolaou P., North WG, et al: Systemic and regional hemodynamic effect of endogenous vasopressin stimulation in rats. Am J Physiol243:H560-565, 1982.
6.
Pang Ccy: Effect of vasopressin antagonist and saralasin on regional blood flow following hemorrhage. Am J Physiol245:H749-755, 1983.
7.
Reid IA: Inhibition of renin secretion by vasopressin: Mechanism and physiological role. In: Vasopressin, ed. by Schrier RW.New York: Raven Press , 1985, pp 21-22.
8.
Toba K., Ouchi Y., Liang J., et al: Role of central vasopressin in cardiovascular regulation: Effect of dehydration and sex. Gerontology40 (suppl 12):16-22, 1994.
9.
Toba K., Ouchi Y., Liang J., et al: Effect of an intracerebroventricularly administered vasopressin V1 antagonist on blood pressure and heart rate in deoxycorticosterone-salt hypertensive rats. Autonomic Nervous System (in press).
10.
Tagawa T., Imaizumi T., Endo T., et al: Vasodilatory effect of arginine vasopressin is mediated by nitric oxide in human forearm vessels. J Clin Invest92:1483-1490, 1993.
11.
Hirsh AT, Dzau VJ, Majzoub JA, et al: Vasopressin-mediated forearm vasodilation in normal humans. Evidence for a vascular vasopressin V2 receptor. J Clin Invest84:418-426, 1989.
12.
Imaizumi T. , Harada S., Hirooka Y., et al: Effect of OPC-21268, an orally effective vasopressin V1 receptor antagonist in humans. Hypertension (Dallas) 20:54-58, 1992.
13.
Suzuki S., Takeshita A., Imaizumi T., et al: Biphasic forearm vascular responses to intraarterial arginine vasopressin. J Clin Invest84:427-434, 1989.
