Subdural hematomas are well known but infrequent complications of throm bolytic therapy. Although these are usually associated with head trauma, the authors describe a case of a patient who received a particularly aggressive thrombolytic regimen and presented six months later with complaints of noth ing more than a headache resistant to medical therapy, without associated neu rologic manifestations, which was finally diagnosed as a chronic subdural hematoma by computerized tomography. In the era of thrombolysis, physicians should maintain a heightened index of suspicion for subdural hematoma in pa tients complaining of headache.